Carcinogenicity studies overview

An overview of the reactions over zeolites and related materials employed in the fields of refining, petrochemistry, and commodity chemicals reviewed the role of carbocations in these reactions.15 An overview appeared of the discovery of reactive intermediates, including carbocations, and associated concepts in physical organic chemistry.16 The mechanisms of action of two families of carcinogens of botanical origin were reviewed.17 The flavanoids are converted to DNA-reactive species via an o-quinone, with subsequent isomerization to a quinone methide. Alkenylbenzenes such as safrole are activated to a-sulfatoxy esters, whose SnI ionization produces benzylic cations that alkylate DNA. A number of substrates (trifluoroacetates, mesylates, and triflates) known to undergo the SnI reaction in typical solvolysis solvents were studied in ionic liquids several lines of evidence indicate that they also react here via ionization to give carbocationic intermediates.18... 

Dyes, and espedally azo dyes, compounds of environmental concern because of their carcinogenic potential, were studied with TSP-LC-MS [28, 201]. An overview presented current methodologies for determining sulfonated azo dyes in environmental waters using TSP [200]. Results obtained by LC-MS and capillary zone electrophoresis (CZE) MS, coupled with TSP-, APCI-, and ESI interface were discussed [43]. 

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