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Carcinogenesis testing, tissue

Rationale for Using a Tissue Culture System in Metal Carcinogenesis Testing... [Pg.76]

For the agent, mixture or exposure circumstance being evaluated, the available data on end-points or other phenomena relevant to mechanisms of carcinogenesis from studies in humans, experimental animals and tissue and cell test systems are summarized within one or more of the following descriptive dimensions ... [Pg.22]

TCDD are associated with alterations of cell proliferation in affected tissues. Common examples of 2,3,7,8-TCDD-mediated differentiation and proliferation in both fishes and mammals include dermal hyperkeratinization (fin necrosis in fish), teratogenicity, lymphoid involution, immunotoxicity, and carcinogenesis. Lipid peroxidation in liver, kidney, thymus, and testes is induced in rats by 2,3,7,8-TCDD in a dose- and time-dependent maimer. The enhanced lipid peroxidation by microsomes from 2,3,7,8-TCDD-treated rats may be associated with an increase in hydrogen peroxide production in conjunction with a decrease in glutathione peroxidase activity and an increase in free iron. [Pg.264]

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Carcinogenesis

Carcinogenesis testing

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