Carboxylic Acids and Their Derivatives Nucleophilic Addition-Elimination at the Acyl Carbon

CHAPTER 17 CARBOXYLIC ACIDS AND THEIR DERIVATIVES Nucleophilic Addition-Elimination at the Acyl Carbon... [Pg.772]

CHAPTER 17 CARBOXYLIC ACIDS AND THEIR DERIVATIVES Nucleophilic Addition-Elimination at the Acyl Carbon 17.53 An alternative synthesis of ibuprofen is given below. Supply the structural formulas for compounds A-D ... [Pg.820]

CARBOXYLIC ACIDS AND THEIR DERIVATIVES NUCLEOPHILIC ADDITION-ELIMINATION AT THE ACYL CARBON... [Pg.389]

The reactions of carboxylic acids and their derivatives are characterized by nucleophilic addition—elimination at their acyl (carbonyl) carbon atoms. The result is a substitution at the acyl carbon. Key to this mechanism is formation of a tettahedtal intermediate that returns to a carbonyl group after the elimination of a leaving group. We shall encounter many reactions of this general type, as shown in the following box. [Pg.784]