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Carboxyl-protecting groups

D-Glucuronic acid (d-GIcA) L-lduronic acid (i-ldoA) [Pg.63]

SCHEME 3.9 Formation of the methyl ester of D-glucuronic acid. [Pg.63]

To direct the synthesis so that only Phe Gly is formed the ammo group of phe nylalanme and the carboxyl group of glycine must be protected so that they cannot react under the conditions of peptide bond formation We can represent the peptide bond for matron step by the following equation where X and Y are amine and carboxyl protecting groups respectively... [Pg.1136]

Developed as a carboxyl protective group for peptide synthesis because of its stability to hydrogenolysis and acidic conditions, the acetol (hydroxy acetone) ester is prepared by DCC coupling (68-92% yield) of the acid with acetol. It is cleaved with TBAF in THF. ... [Pg.393]

Relative Lability of Aspartic Acid )8-Carboxyl Protective Groups ... [Pg.403]

Carboxyl Protective Group Abbreviation Deprotection time... [Pg.403]

Enzyme Labile Carboxyl Protecting Groups Choline Ester (OCho)... [Pg.373]

To overcome these difficulties in the selective deprotection and chain extension, several carboxyl-protecting groups, namely, allyl (16,32), benzyl (43,44), tert-butyl (42), 2-bromoethyl (45), 2-chloroethyl (45), heptyl (46), 4-nitrophenyl (47,48), and pentafluorophenyl (49) for L-serine/L-threonine have been introduced or applied. Similarly, amino-protecting groups for L-serine/L-threonine that have proved useful for the synthesis of glycopeptides are tm-butyloxycarbonyl (50), 9-fluorenylmethoxycarbonyl (43,44,48), 2-(2-pyridyl)ethoxycarbonyl (51), 2-(4-pyridyl)ethoxycarbonyl (44,52), and 2-triphenylphosphonioethoxycarbonyl (53). Some applications of these groups have been discussed in earlier reviews (7-11). [Pg.287]

Different Amino and Carboxyl Protecting-Group Combinations of L-Serine/L-Threonine Used for Glycopeptide Chain-Lengthening... [Pg.294]

RW Roeske. Carboxyl protecting groups, in The Peptides Analysis, Synthesis, Biology, Vol. 3, pp 101-136, Academic Press, New York, 1981. [Pg.279]

Some Amine and Carboxyl Protecting Groups Used in Peptide Syntheses... [Pg.1239]

Briand, B., Kotzur, N., Hagen, V. and Beyermann, M. (2008) A new photolabile carboxyl protecting group for native chemical ligation. Tetrahedron Letters, 49, 85-87. [Pg.441]

While the conventional carboxylate protecting groups interfere with the course of the reaction, the enantioselective epoxidation on the oxazole 77b followed by photo-oxygenation and hydrolysis of triamide 78b affords the ester 79 in good yield with the desired stereochemistry [76b], Starting from alkoxyoxazoles, rearrangement to dioxetanes [75b] or dioxazoles [75] has been observed, and a simple and high-yield route for stable 377-1,2,4-dioxazoles 80 has been described (Sch. 46) [77]. [Pg.327]

Finally, the carboxyl protecting group is removed by saponification ... [Pg.1152]

Figure 21. General scheme for isopeptide bond formation between amino and carboxyl side groups of proteins and additional amino acids. X and Z are amino and carboxyl protecting groups, respectively Y is a carboxyl-activating group (114). Figure 21. General scheme for isopeptide bond formation between amino and carboxyl side groups of proteins and additional amino acids. X and Z are amino and carboxyl protecting groups, respectively Y is a carboxyl-activating group (114).
Simplicity, low steric bulk, simple NMR spectra, and ease of preparation are prime assets making methyl esters the most common of the carboxyl protecting groups. [Pg.384]

See other pages where Carboxyl-protecting groups is mentioned: [Pg.259]    [Pg.426]    [Pg.7]    [Pg.1034]    [Pg.278]    [Pg.156]    [Pg.546]    [Pg.1355]    [Pg.332]    [Pg.267]    [Pg.1239]    [Pg.1247]    [Pg.137]    [Pg.100]    [Pg.145]    [Pg.145]    [Pg.154]    [Pg.209]    [Pg.209]    [Pg.112]    [Pg.379]    [Pg.158]    [Pg.114]    [Pg.382]    [Pg.385]    [Pg.386]    [Pg.389]    [Pg.390]    [Pg.392]    [Pg.393]    [Pg.394]    [Pg.396]    [Pg.399]   
See also in sourсe #XX -- [ Pg.64 ]



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2- ethyl esters protect carboxyl groups

2- ethyl esters, to protect carboxyl groups

2-Phenyl-2- anthrylmethyl esters to protect carboxyl groups

A-carboxyl group, protection

Benzyl esters, to protect carboxyl groups

Bis methyl esters, to protect carboxyl groups

Carboxyl groups, protection

Carboxyl groups, protection

Carboxyl groups, protection 472 INDEX

Carboxyl groups, protection Carboxylic acids

Carboxyl groups, protection alcohols

Carboxyl groups, protection aldehydes

Carboxyl groups, protection alkynes

Carboxyl groups, protection cleavage

Carboxyl groups, protection enolate alkylation

Carboxyl groups, protection functional group

Carboxyl groups, protection interconversion

Carboxyl groups, protection reduction

Carboxyl groups, protection synthesis, from

Carboxyl groups, protection, 2- ethanol

Carboxylic groups protection

Carboxylic protecting groups for

Common carboxylic acid protecting groups

Esters to protect carboxyl groups

Fluorous carboxylic acid protecting group

Functional group equivalents protected carboxylic acids

Methyl esters, to protect carboxyl groups

Miscellaneous esters to protect carboxyl groups, list

Organozinc compounds as carboxylic acid protecting groups

Orthoester carboxylic acid protecting group

Oxazolines as carboxylic acid-protecting groups

Phenacyl esters, to protect carboxyl groups

Phenyl esters, to protect carboxyl groups

Photoremovable protecting groups carboxylic acids

Protecting groups carboxylic acids

Protecting groups, allyl-based deprotections carboxylic acids

Protecting groups, deprotection carboxylic acids

Protection for the Carboxyl Group

Protection of Carboxyl Groups Esterification

Protection of carboxyl groups

Protection of the Carboxyl Group

Protection of the a-carboxyl group

Protective groups carboxylic acids

Protective groups to protect carboxylic acids

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