Carboxy-methyl-dextran

GRGDS, GRGES, GREDVDY, GSVVYGLR Carboxy-methyl- dextran HUVEC, human foreskin fibroblasts Noncontact printing of peptides onto activated hydrogel 2007 [161]... 

Physicochemical studies have also been performed on carboxymethyl-ated 0-methyl- and 0-(2-hydroxyethyl)-cellulose. As with other car-boxymethylated polysaccharides, the degree of substitution and the distribution of substituents play a dominant role in the viscosity of aqueous solutions of O-(carboxymethyl)starch. Viscosimetric "" and other measurements indicate that 0-(carboxymethyl)amylose exists as a random coil in solution, " and that the chains are stiffer than the corresponding cel-lulosic chains whereas the stiffness of the chains of 0-(carboxy-methyl)dextran is little different from that of other charged ether derivatives of dextran and dextran sulfate. Fractional precipitation is a useful procedure for obtaining homogeneous fractions of carboxymethylated polysaccharides, as with other polysaccharide ethers. Acetylated O-(carboxymethyl) cellulose provides a useful basis for the formation of desalination membranes. ... 

Zhang, R., Tang, M., Bowyer, A., Eisenthal, R. Hubble, J. 2005, A novel pH-and ionic-strength-sensitive carboxy methyl dextran hydrogel . Biomaterials, yol. 26, no. 22, pp. 4677-4683. 

Murray G, Stack K, McLean D, Shen W, Gamier G (2009) Mechanism of pitch adsorption on carboxy methyl dextran surfaces. Appita J 1 64... 

Other ionic interactions can be exploited to create microgels or nanogels. Chitosan and carboxy-methyl chitosan have been associated to formulate nanoparticles containing tea polyphenols for sustained release of these antitumor compounds, Gelatin-dextran conjugates have been cross-linked with TPP for tea polyphenol delivery. ... 

The reaction of dextran with epichlorohydrin results in a cross-linked gelatinous product that is used as a molecular sieve for separation and purification of biochemically important macromolecules like proteins, polysaccharides or nucleic acids. Its commercial name Sephadex is derived from SEparation PHArmacia DEXtran and stands for many different successful products including further derivatized materials such as carboxy-methyl, diethylaminoethyl, diethyl(2-hydroxypropyl)-aminoethyl, and sulfo-propyl Sephadex . 

Numerous ethers of cellulose, starch, and bacterial dextran are of established or potential industrial importance. (See also Chapter XII.) Treatment of the polysaccharides with alkali and methyl chloride, ethyl chloride, benzyl chloride, ethylene oxide (or ethylene chlorohydrin), sodium chloro-acetate, and allyl bromide gives, respectively, the methyl, ethyl, benzyl, hydroxy ethyl, carboxy methyl, and allyl ethers. The cellulose derivatives... 

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