Carboplatin allergic reactions

The major advantage of carboplatin over cisplatin is a markedly reduced risk of toxicity to the kidneys, peripheral nerves, and hearing additionally, it produces less nausea and vomiting. It is, however, more myelo-suppressive than cisplatin. Other adverse effects include anemia, abnormal liver function tests, and occasional allergic reactions. 

Cisplatin can cause anaphylactic shock, asthma, or urticaria (236). Hypersensitivity reactions, probably of type I, have also been reported after the administration of cisplatin, carboplatin, and oxaliplatin (237-243). Life-threatening allergy to cisplatin has also been reported after 16 doses of cisplatin 20 mg/m /week (244). These allergic reactions can include respiratory dysfunction (for example wheezing, dyspnea), gastrointestinal discomfort (for example abdominal cramps, diarrhea), and rashes (for example pruritus, urticaria, facial erythema, and swelling). The risk of exfoliative dermatitis is very low. In most patients, the first signs of hypersensitivity reactions usually occurred after the administration of multiple intravenous courses... 

Hendrick AM, Simmons D, Cantwell BM. Allergic reactions to carboplatin. Ann Oncol 1992 3(3) 239-40. 

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