Carbon monoxide Terms Links

Other mechanisms have also been implicated in odor adaptation, including cAMP-dependent phosphorylation of ciliary proteins via protein kinase A G-protein-receptor kinase activity (GRK3), possibly via phosphorylation of the OR Ca2+/calmodulin kinase II (CaMKII) phosphorylation of ACIII cGMP and carbon monoxide [ 31 ]. These latter three mechanisms have been particularly linked to longer-lasting forms of adaptation, on the order of tens of seconds (for CaMKII) or minutes (CO/cGMP). Together with the short-term adaptation described above, these various molecular mechanisms provide the OSN with a number of ways to fine-tune odor responses over time. 

The carbon monoxide molecule can be described in conventional valence bond terms as having two canonical forms one having the carbene-like structure in which divalent carbon is linked to oxygen by a double bond and the other a dinitrogen-like form, in which both atoms carry a lone pair and are linked by a triple bond [Eq (2.1)]. 

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