Carbohydrate-protein linkages proteoglycans

These conformations were subjected to a combined MD/EM refinement using the NOESY derived constraints as pseudoenergy functions. Families of conformations for the whole molecule were then constructed from the structures derived for each linkage. This procedure was demonstrated on a fragment from the carbohydrate-protein linkage region of connective tissue proteoglycans. 

We will illustrate our methodology using 0-3-D-galactopyranosyl -(1->4) 0-3 D-xylopyranosyl-(1->0)-L-serine (GXS), a fragment from the carbohydrate-protein linkage region of xylose/serine linked proteoglycans. 

MOLECULAR STRUCTURE OF THE CARBOHYDRATE-PROTEIN LINKAGE REGION FRAGMENTS FROM CONNECTIVE-TISSUE PROTEOGLYCANS... 

Oligosaccharide Fragments Isolated from the Carbohydrate-Protein Linkage-Region of Dermatan Sulfate Proteoglycans 1... 

Sugahara K, Yamashina 1, Dewaard P, Vanhalbeek H, Vhegen-thart JFG. Structural studies on sulfated glycopeptides from the carbohydrate-protein linkage region of chondroitin 4-sulfate proteoglycans of swarm rat chondrosarcoma - demonstration of 86. the structure Gal(4-0-Sulfate)-P-l-3-Gal-P-l-4Xyl-P-l-0-Ser. J. 

Rio, S, Beau, J-M, Jacquinet, J-C, Synthesis of glycopeptides from the carbohydrate-protein linkage region of proteoglycans, Carbohydr. Res., 219, 71-90, 1991. 

R421 N. R. Krishna and P. K. Agrawal, Molecular Structure of the Carbohydrate-Protein Linkage Region Fragments from Connective-Tissue Proteoglycans , Adv. Carbohydr. Chem. Biochem., 2001, 56, 201... 

Rama Krishna N, Agrawal PK. Molecular structure of the carbohydrate-protein linkage region fragments from connective tissue proteoglycans. Adv Carbohydr Chem Biochem 2000 56 201-234. 

Using structural formulas, descirbe the two major types of linkage of carbohydrate chains or clusters to proteins to form glycoproteins or proteoglycans. 

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