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Indanyl sodium

Chemical Name N-(2-carboxy-3,3-dimethvl-7-oxo-4-thia-1-azabicyclo[3.2.0I hept-6-yl)-2-phenylmalonamic acid, 1-(5-indanyl ester), monosodium salt [Pg.237]

Various isolation methods are then spelled out in U.S. Patent 3,679,801. [Pg.237]

Chemical Name 3/3-hydroxy-11-oxo-20/3-olean-l2-en-29-oic acid hydrogen butanedioate Common Name Glycyrrhetinic acid hydrogen succinate Structural Formula  [Pg.238]

Trade Name Manufacturer Country Year Introduced [Pg.238]

One molecular proportion of glycyrrhetinic acid hydrogen succinate was ground with a dilute (5%) aqueous solution containing two molecular proportions of sodium hydroxide. [Pg.239]

Pfizer-Taito Pfizer -Roerig Pfizer-Roerig [Pg.237]

Tablets, film-coated 382 mg carbenicillin (118 mg indanyl sodium ester) Rx)... Tablets, film-coated 382 mg carbenicillin (118 mg indanyl sodium ester) Rx)...
Carbenicillin indanyl sodium is an antipseudomonal penicillin formulated for oral administration. The drug achieves negligible carbenicillin concentrations in the urine of patients with renal failure. Consequently, carbenicillin is not appropriate for patients with renal failure. In patients with normal renal function, however, carbenicillin indanyl sodium is used to treat urinary tract infections caused by P. aeruginosa, Proteus spp., and Escherichia coli. [Pg.530]

Carbenicillin Indanyl Sodium, USP. Efforts to obtain orally active forms of carbcnicillin led to the eventual rclea.se of the S-indanyl ester carbenicillin indanyl. 6- 2-phcnyl- 2-(S-indanyloxycarbonyl)acctamidolpenicillanic acid (Geocil-lin). in 1972. Approximately 40 >(- of (he usual oral dose of indanyl carbenicillin is absorbed. After ab.sorption. the ester is hydrolyzed rapidly by plasma and tissue e.stcrases to yield carbcnicillin. Thu.s. although the highly lipophilic and highly protein-bound e.ster has in vitro activity comparable with that of carbenicillin. its activity in vivo is due to carbenicillin. Indanyl carbenicillin thus provides an orally active alternative for (he treatment of carbenicillin-sensiiivo sy.stcmic and urinary tract infections caused by Pseudomonas spp.. indole-positive Proteus. spp.. and seleeted species of Gramnegative bacilli. [Pg.313]

See other pages where Indanyl sodium is mentioned: [Pg.237]    [Pg.237]    [Pg.1613]    [Pg.1681]    [Pg.1703]    [Pg.1703]    [Pg.1703]    [Pg.1752]    [Pg.1752]    [Pg.352]    [Pg.1445]    [Pg.192]    [Pg.988]    [Pg.827]    [Pg.827]    [Pg.828]    [Pg.352]    [Pg.972]    [Pg.65]    [Pg.67]    [Pg.690]    [Pg.237]    [Pg.237]    [Pg.1613]    [Pg.1681]    [Pg.1703]    [Pg.1703]    [Pg.1703]    [Pg.1752]    [Pg.1752]   
See also in sourсe #XX -- [ Pg.44 , Pg.289 ]



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