Carb oxylic acids

Under irradiation in diethyl ether, the dextrorotary enantiomer of 3,6-hexanooxepin-4-carb-oxylic acid rearranges to the oxabicyclo[3.2.0]heptadiene system with retention of the optical activity.36... [Pg.45]

C2JH19F3N6O7S3 104145-96-2) see Cefditoren pivoxil [6lf-[3(Z),6a,7p(Z)]]-7-[[(2-amino-4-thiazolyl)(meth-oxyimmo)acetyl]aminoJ-3 [2-(4>methyl-5-thiazolyl)eChe-nyl]-8-oxo>5-thia-l-azablcyclo[4.2.0Joct-2-ene-2>carb oxylic acid monosodiiim salt ... [Pg.2298]

C12H10 92-52-4) see Bifonazole Fenbufen 4-biphenylacetonitrile (C14H11N J760i-77-7) see Felbinac [3aR-(3aa,4a,5p,6aa)]-[l,l -biphenyl]-4-carboxylic acid 4-formylhexahydro-2-oxo-2fl-cyclopenta[6]furan-5-yl ester (C2iH,80j 38754-71-1) see Latanoprost [3alt-[3aa,4a(l ,35 ),5p,6aa]]-[4,4 -biphenyl]-4-carb-oxylic acid hexahydro-4-(3-hydroxy-5-phenyl-l-pentenyl)-2-oxo-21/-cyclopenta[6]furan-5-yl ester (C3 H ,05 41639-73-0) see Latanoprost... [Pg.2308]

C15HHCI2NO 92428-58-5) see Clomipramine 3-chloro-10,ll-dihydro-5H-dibenz[i4/]azepine-5-carb-oxylic acid 3-(dimethylamino)propyl ester (C20H23CIN2O2 94758-20-0) see Clomipramine... [Pg.2326]

The synthesis and antibacterial properties of norfloxacin (2a) were described in 1980 [65]. In this key paper in the evolution of quinolone antibacterial agents, a series of 6,7,8-polysubstituted-l-ethyl-l,4-dihydro-4-oxoquinoline-3-carb-oxylic acids (13) was synthesized, employing previously developed quantitative structure-activity relationships (QSAR) for the corresponding 6-, 7- and 8-monosubstituted derivatives versus Escherichia coli. The QSAR analysis... [Pg.248]

The first assignment of the chirality (absolute configuration) to a planar chiral phane ([2.2]paracyclophanecarboxylic acid 23, in 1968),04) was deduced from the results of a kinetic resolution of its (racemic) anhydride with (—)-l-phenylethyl-amine and is based on the related topology of 23 and 2-methyl-metallocene-l-carb-oxylic acids 19). For these chiral compounds, this method had given (correct) results, as confirmed afterwards by the Bijvoet method 109). Since this method has been reviewed in some detail19,100) it will not be discussed in this survey. [Pg.47]

Ethyl cyc/opropane-carboxylate. Use 22 g. of cycfopropane-carb-oxylic acid (Section V,33) and 40 g. (24-5 ml.) of redistilled thionyl chloride to prepare the acid chloride, b.p. 118-119° (22 g.). Treat the latter with 10-1 g. of absolute ethyl alcohol. The yield of ethyl cyclo-propane-carboxylate, b.p. 132-133°, is 13 g. [Pg.390]

Esters of racemic pyrazolidine-3-carboxylic acid (5-azaproline, 16) are obtained by a two-step reaction via addition of diazomethane to acrylic acid esters to form the corresponding dihydropyrazoline derivatives, which are converted into the desired pyrazolidine-3-carb-oxylic acid derivative by hydrogenation over palladium on charcoal,11621 or by reduction with sodium cyanoborohydride,[164l or with zinc in acetic acid. Details are given in Table 6J1651... [Pg.71]

Ci H25N507S 37661-07-7) see Bacampicillin D(-)-tx-azidophenylacetic acid (C,H7N202 29125-25-5) see Azidocillin [ZS -[2a,5a,6P(S )]J-6-[(azidophenylacetyl)amino]-3,3-di-methyI-7-oxo-4-thia-l-azabicyclo[3.2.0]heptane-2-carb-oxylic acid (2,2-dimethyl-l-oxopropoxy)methyl ester (C22H27N. 06S 26255-15-2) see Pivampicillin... [Pg.2301]

Dihydro-5-oxo-l-( 4-sulfophenyl )-lH-pyrazole-3-carb-oxylic Acid, Disodium Salt Not more than 0.2%. [Pg.166]

Quinoxaline-2-carboxylic acids readily undergo decarboxylation. 3-Chloroquinoxaline-2-carb-oxylic acid undergoes decarboxylation at relatively high temperatures to give 2-chloroquinox-aline. ... [Pg.226]

Fieser and Holmes [35], by the addition of butadiene and dimethyl-butadiene to ethyl 3 4-dihydro-a-naphthoate, were able to prepare [cxn, R = H] and [cxn, R = Me], and also the methoxy-compounds [cxm] and [cxiv] in a similar way [36], Reduction of [cxiv] afforded 3 4-dimethoxy-5 6 7 8 9 10 13 14-octahydrophenanthrene-13 -carb -oxylic acid [cxv], which is theoretically obtainable from [cxvi], a known product of degradation of thebaine [37].. Attempts to convert the carboxyl group of [cxv] to other substituents were made, and in this connexion [oxii, R = Me] was submitted to the Bouveault-Blano reduction followed by treatment of the product with phosphorus... [Pg.407]

On treatment with silver tetrafluoroborate in boiling aqueous methanol, 7,7-dichlorobi-cyclo[3.2.0]heptan-6-one afforded exclusively exu-6-chlorobicyclo[3.1.0]hexane-en /o-6-carb-oxylic acid 19 (R = H) and its methyl ester 19 (R = Me) in 24 and 11.5% yield, respectively. ... [Pg.1035]

Penicillin BT. 6-[[(Butylthio)acetyl]amino]-i,3-dimethyl-7-oxo-4-thia-l-azabicyclo[3.2.0jheptane-2-carb-oxylic acid but ylmercaptomethy I penicillin butylthjomefhy] -... [Pg.1122]

RADO(Et)-OH (lS,5R,8R)-3-Ethyl-2-oxo-3-aza-6,9-dioxabicyclo[3.2.1]nonane-7-carb-oxylic acid... [Pg.188]

B is (4-aminophenyl)-quinoxaline-6-carb-oxylic acid 2.3- B is (4-aminophenyloxyphenyl)-quinoxal-ine-6-carboxylic acid Hyperbranched polymers Hyperbranched polymers... [Pg.424]

YeJlow leaflets from EtOH. M.p. 281°. Sd. EtOH and AcOH but less so than the 1-carb oxylic acid. Si. sd. Et20, CgHg. Insd. ELgO. Sol. alkalis to sols, snowing blue fluor. Sublimes in. leaflets and needles. GaO—> anthracene,... [Pg.170]

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