Cannabis constituents

The first successful attempt to identify a typical cannabis constituent (today called cannabinoid) was achieved by Wood who isolated cannabinol... [Pg.55]

A second cannabis constituent, cannabidiol (CBD) was also isolated, but its structure was only partially clarified. Synthetic tetrahydro-cannabinols, which showed cannabis-like activity in animal tests, were prepared, but they obviously differed from the active natural product, on the basis of their UV spectrum. [Pg.55]

Malfait AM, Gallily R, SumariwaUa PF, The non-psycho active cannabis-constituent cannabidiol is an oral anti-arthritic therapeutic in murine coUagen-induced arthritis. Prod Nat Acad Sci USA 97 9561—9566, 2000. [Pg.426]

Ottersen, T., A. Aasen, F. S. El-Feraly and C. E. Turner. X-ray structure of cannabispiran A novel cannabis constituent. Chem Commun 1976 1976 580. [Pg.97]

Evans. Actions of cannabis constitu- CS238 ents on enzymes of arachidonate metabolism Anti-inflammatory... [Pg.104]

Crofford LJ (1997) COX-1 and COX-2 tissue expression implications and predictions. J Rheumatol 24, Suppl 49 15-19 Cromlish WA, Kennedy BP (1996) Selective inhibition of cyclogenase-1 and -2 using intact insect cell assays. Biochem Pharmacol 52 1777-1785 Evans AT, Formukong EA, Evans FJ (1987) Actions of cannabis constituents on enzymes of arachidonate metabolism anti-inflammatory potential. Biochem Pharmacol 36 2035-2037... [Pg.241]

Aiylation with a homocuprate. A key step in a synthesis of the cannabis constituent 4 is the reaction of 1 with the homocuprate derived from olivetol dimethyl ether (2) hy regiospecific lithiation followed by reaction with CuBr. The cuprate does not react with 1 in the absence of a Lewis acid, but in the presence of BF, etherate (3.5 equiv.) ( —)-3 is obtained in 78% yield with high regio- and stereospecificity. The dihydrobromide of... [Pg.69]

Cannabis constituents Cannabicyclol Cannabidiol Cannabigerol Cannabinol... [Pg.197]

The papers published on the chemistry of Cannabis constituents up to 1970 have been summarized by two authors,and an extensive treatment of its botany and chemistry is available as a book. The field is still plagued by the differences in numbering systems which are used in this review the mono-terpene type [as shown in A -tetrahydrocannabinol (332), = A THC] is employed, since it can be used for all cannabinoids, and is immediately comprehensible to anyone familiar with the chemistry of monoterpenes. ... [Pg.60]

Cannabis constituents (alkaline hydrolysis of urine followed by SPE )... [Pg.709]

Hollister, L.E. Structure-activity relationships in man of cannabis constituents and homologs and metabolites of delta-9-TliC. Pharmacology 11 3-11,1974. [Pg.28]

A >tetrahydrocannabinol is one of the active principles of cannabis (constituent of marijuana or hashish from Cannabis sativa) with lower psychoactivity than A -tetrahydrocannabinol. It is a cannabinoid receptor agonist and has (euphoric) sedative and mild PSYCHOTROPIC (hallucinogenic) properties, and ANTIEMETIC activity. A >tetrahydrocannabinol (A -tetrahydrocannabinol) is an active cannabinoid. It is a constituent of marijuana. The active (6aR,10aR)-(-)-trans-form = dronabinol. It is a CANNABINOID RECEPTOR AGONIST and has (euphoric) SEDATIVE and mild PSYCHOTROPIC (hallucinogenic) properties, and ANTIEMETIC activity. [Pg.271]

The very low water solubility of key cannabis constituents aggravates still further the well-known variability of absorption from the gastro-intestinal tract, resulting in poor predictability of both the timing and intensity of peak effects by the oral route. Titration of dose against symptom relief, as is the norm for most individuals who smoke cannabis medicinally, is very difficult in these circumstances. An additional drawback is the production of larger quantities of the reputedly psychoactive metabolite 11-OH-THC as a result of the hepatic first-pass phenomenon. The use of whole plant cannabis-based medicinal extracts in liquid form delivered by a pump action oromucosal spray (Whittle et al. 2001) represents an attempt to overcome these problems and permit the patient to self-titrate to an optimal individualised daily dose. [Pg.725]

Introduction to Analysis for Cannabis Constituents, Especially Smoke and Body Fluids... [Pg.174]

Boeren EG, Elsohly MA, Turner CE (1979) Cannabiripsol a novel Cannabis constituent. Experientia 35 1278... [Pg.3432]

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