Cannabinoids prevalence

Cannabinoid receptors, the binding sites for THC from marijuana, are prevalent in the brain and concentrated in areas like the basal ganglia, hippocampus, cerebellum, and cerebral cortex (indicated in pink on this illustration). THC interrupts the normal communication between neurotransmitters and results in changes of behavior and physical effects controlled by these areas of the brain. 

Concerns have been raised about the possible adverse effects of acute as well as chronic medicinal and recreational use of cannabis on cognition and the body (104). The author, while acknowledging the therapeutic role of cannabinoids in the management of pain and other conditions, expressed concern that in recent years the prevalence of recreational cannabis use (especially in the young) and the potency of the available products have markedly increased in the UK. 

The prevalence of these side-effects is a serious limiting factor in the clinical applicability of cannabinoids by systemic administration. 

Himter, C. E., R. J. Lokan, M. C. Longo, J. M. White and M. A. White (1998). The prevalence and role of alcohol, cannabinoids, benzodiazepines and stimulants in non-fatal crashes. Forensic Science, Department for Administrative and Information Services. Adelaide, Southern Australia. 

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