Aspartate proteases, Candida albicans secretion

Candida albicans secreted aspartic protease Pepsin ... 

Ellagic acid (polyphenol) Widespread, ellagitannin product Fragaria spp. (Rosaceae) Candida albicans secreted aspartic protease (11 pM) Pepsin (37 pM) [35]... 

Geranyl-2,4,6-trihydrOxy-benzophenone (phenolic ketone) Tovomita krukovii (Clusiaceae) Candida albicans secreted aspartic protease (109 pM) [36]... 

A number of plant natural products have been isolated that inhibit an aspartic protease secreted by Candida albicans [35, 36], the most potent of which (IC50 values 8-14 pM) are the phenolics ellagic acid [35] and mattucinol-7-0-[4",6"-0-(5)-hexahydroxydiphenoyl]-P-glucopyranoside [35] and the triterpene betulinic acid [36] (Table 1). A macromolecule from Anchusa is a potent inhibitor of pepsin (K 20 nM) [37] (Table 1). 

Borg-von Zepelin M, Meyer I, Thomssen R, Wurzner R, Sanglard D, Telenti A, Monod M HIV-protease inhibitors reduce cell adherence of Candida albicans strains by inhibition of yeast secreted aspartic proteases. J Invest Dermatol 1999 13 747-751. 

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