Cancers anti-cancer agents

Allen TM, Cheng WWK, Hare 11, Laginha KM. Pharmacokinetics and pharmacodynamics of Upidic nano-particles in cancer. Anti-Cancer Agents Med. Chem. 2006 6 513-523. 

King AN, Beer DG, Christensen PJ, Simpson RU, Ramnath N (2010) The vitamin D/CYP24A1 story in cancer. Anti-cancer Agents Med Chem 10 213-224... 

K. hici, T. Kataoka, T. Ando, The use of lentinan for treating gastric cancer, Anti-Cancer Agents Medicinal Chem., 13,681-688,2013. 

The recent links made between mTORCl and tumor suppressors/oncoproteins suggests that aberrantly high mTORCl activity may be the underlying cause of hamartomas and perhaps some cancers. Based on this, many clinical trials are underway to determine the efficacy of rapalogs as anti-cancer agents. Current phase III clinical trials include ... 

However, an almost classical attempt to generate an a, -unsaturated e-capro-lactam 87 involved a Knoevenagel condensation of 86 as the ring forming step. The material was employed in a synthesis of conformationally restricted analogs of some anti cancer agents (tetrahydrofolate analog) (Scheme 17) [24]. 

Baldwin R.W. (1985) Monoclonal antibody targeting of anti-cancer agents. EurJ Cancer Clin Oncol, 21, 1281-1285. 

Sordet O, Khan QA, Konh KW, Pommier Y (2003) Cmr Med Chem Anti-Cancer Agents 3 271... 

Another anti-cancer agent in clinical use is podophyllotoxin (3-59) this has an aryl tetrahydronaphthalene lignan lactone skeleton, and demonstrates potent tubulin-binding, anti-mitotic properties (Scheme 3.16) [30]. The Sherburn group [31] prepared this molecule by a tris(trimethylsilyl)silane promoted conversion of thionocarbonate 3-55 into the lactone 3-58, which proceeded with a yield of 38 %. As intermediates, the radicals 3-56 and 3-57 can be assumed. 

M. P. Edwards, Discovery of cMet Kinase Inhibitors as Potential Anti-Cancer Agents, 11th Annual San Diego Med. Chem. Symposium, UCSD, California, July, 2008. 

Quinoxaline bis-A-oxides have been investigated as potential anti-cancer agents 93 <06BMC6917> and anti-trypanosomal agents 94 <06BMC5503>. In the latter case, a vanadyl complex was prepared in order to increase bioavailability. 

The answer is c. (Hardman, pp 1260—1262.) Paclitaxel is a large structural molecule that contains a 15 membered taxane ring system. This anti cancer agent is an alkaloid derived from the bark of the Pacific yew tree. Its chemotherapeutic action is related to the microtubules in the cell. Paclitaxel promotes microtubule assembly from dimers and causes microtubule stabilization by preventing depolymerization. As a consequence of these actions, the microtubules form disorganized bundles, which decreases... 

The immunostimulatory activity of IL-2 has proven beneficial in the treatment of some cancer types. An effective anti-cancer agent would prove not only medically valuable, but also commercially very successful. In the developed world, an average of one-in-six deaths is caused by cancer. In the USA alone, the annual death toll from cancer stands in the region of half a million people. 

The initial interest in utilizing TNF as a general anti-cancer agent has diminished, largely due to the realization that ... 

Thrombolytic agent Thrombolytic agent Anticoagulant Haemophilia B Anti-cancer agent Cystic fibrosis Gaucher s disease Fabry disease Hyperuricaemia Mucopolysaccharidosis Oxygen toxicity Pompe disease... 

De Medina P, Favre G, Poirot M (2004a) Multiple targeting by the antitumor drug tamoxifen a structure-activity study. Curr Med Chem Anti-Cancer Agents 4(6) 491-508... 

Wiseman H, Cannon M, Arnstein HR, Barlow DJ (1992a) The structural mimicry of membrane sterols by tamoxifen evidence from cholesterol coefficients and molecular-modelling for its action as a membrane anti-oxidant and an anti-cancer agent. Biochim Biophys Acta 1138(3) 197-202... 

Catharanthus roseus) [9]. Maytansine (3) is an ansa macrolyde isolated from Maytenus ovatus [10], and rhizoxin (4) is an antitumor macrolide isolated from the fungus Rhizopus chinensis [11]. Another very important tubulin interactive anti-cancer agent is colchicine (6), and this compound binds to a different binding site of tubulin but is also used in anti-cancer therapy. 

There are a number of reviews published in the field of tubulin binders as anti-cancer agents, but these mostly focus on the cytotoxicity of combre-tastatins and chalcones [1,40,41], There has also been much published on... 

The synthesis of the promising anti-cancer agent epothilone A 75 and many analogues thereof by means of RCM is comprehensively reviewed in the chapter by K.C. Nicolaou et al., this volume, and will not be duplicated here [35]. 

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