Cancer treatment boron neutron capture therapy

Most of the known Cr hydride complexes are the 7r-donor, sandwich-type carborane complexes,676,677 which are described in the Comprehensive Organometallic Chemistry series. Recently, a pendant-arm Cr111 carborane complex containing a pyridine donor (143) has been prepared and characterized by spectroscopic methods.678 Complexes of this type are of interest in the synthesis of new compounds for the treatment of cancer by boron neutron capture therapy and the development of new catalytic systems for alkene polymerization (Section 4.6.5.1.2).678... 

Tietze, L. F., U. Bothe, I. Schuberth, L. F. Tietze, U. Bothe, and I. Schuberth. 2000. Preparation of a new car-boranyl lactoside for the treatment of cancer by boron neutron capture therapy Synthesis and toxicity of fluoro carboranyl glycosides for in vivo F NMR spectroscopy. Chem. Eur. J. 6 836-842. 

Tietze, L. R Bothe, U. Griesbach, U. Nakaichi, M. Hasegawa, T. Nakamura, H. Yamamoto, Y. ortho-Carboranyl glycosides for the treatment of cancer by boron neutron capture therapy. Bioorg. Med. Chem. 2001, 9, 1747-1752. 

One of the most promising appHcations of polyboron hydride chemistry is boron neutron capture therapy (BNCT) for the treatment of cancers (253). Boron-10 is unique among the light elements in that it possesses an unusually high neutron capture nuclear cross section (3.8 x 10 , 0.02—0.05 eV... 

In a cancer treatment called boron neutron-capture therapy, a drug containing boron-10 is injected into a patient where it selectively binds to cancer cells. Irradiating the affected area with neutrons then induces the following reaction ... 

Boron has two stable isotopes, (80.4% abundance) and °B (19.6%). B has a very high neutron absorption cross section (it is a good absorber of neutrons). This property has been developed for use in the treatment of cancerous tumors in a process called boron neutron capture therapy (BNCT). Boron-containing compounds having a... 

Use of dendrimers such as PAMAM, PPI and poly(ether hydro q lamine) (PEHAM) in drug deliveiy is mostly focused on cancer treatment. Dendrimers encapsulate anticancer drugs such as cisplatin and doxorubicin and agents for boron neutron capture therapy and photodynamic therapy. Cisplatin encapsulated dendrimers are reported to increase the bioavailability and selectivity of the drug on a solid tumor model which was provided by injection of B16F10 cells to C57 mice. ... 

BNCT (boron neutron capture therapy) cancer treatment... 

For more than a half century now Boron Neutron Capture Therapy (BNCT) has had potential as a treatment against cancers in difficult-to-access areas of the body. Targets are principally maUgnant brain tumors called glioblastoma multiformehvX also include head and neck cancers involving the Up, mouth, nasal cavities, lymph nodes, sinuses, pharynx, and larynx. How does BNCT work As we know from Table 14.2, boron has two important isotopes, boron-11 (80.22%) and boron-10 (19.78%). It turns out that when B-10 is bombarded with slow or so-called thermal neutrons, an excited, unstable form of boron-11 is formed that immediately disintegrates to produce alpha particles and lithium-7. This process is shown in Equation 14.18. 

The first section consists of three chapters covering the medical uses of boron. Chapter 1 by Lesnikowski describes some of the properties of boron clusters that are important for medical applications and presents some examples of boron clusters in different types of medical applications. The following two chapters describe bioactivity of two specific types of boron compounds carbaboranyl phosphonates (in Chapter 2 by Stadlbauer and Hey-Hawkins) and metal bis(dicarbollides) (Chapter 3 by Konvalinka et al). The former compounds are active as pesticides, bactericides and gameticides, while the later are useful as inhibitors of HIV protease. Both classes have been studied as boron delivery agents for boron neutron capture therapy in cancer treatment. 

Boron neutron capture therapy (BNCT) is one of the most promising methods for cancer treatments. This binary method involves selective introduction of B-10 containing compounds to tumor cells, followed by irradiation with thermal neutrons. BNCT is focused mainly on the treatment of malignant brain tumors, for example, glioblastoma multiforme, which is virtually untreatable via surgery. Two recent publications by Ciofani et al. described BNNTs as a drug carrier for BNCT. ... 

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