Cancer quantum dots

Tada, H., Higuchi, H., Wanatabe, T.M., and Ohuchi, N. (2007) In vivo real-time tracking of single quantum dots conjugated with monoclonal anti-HER2 antibody in tumors of mice. Cancer Res. 67, 1138-1144. 

Smith AM, Dave S, Nie S, True L, Gao X (2006) Multicolor quantum dots for molecular diagnostics of cancer. Expert Rev Mol Diagn 6 231-244... 

Kaul Z, Yaguchi T, Kaul SC, Hirano T, Wadhwa R, Mortalin TK (2003). Imaging in normal and cancer cells with quantum dot immuno-conjugates. Cell Research 13 503-507. 

Cancer is a particularly important disease to treat early, before the disease invades too much tissue. Quantum dots may offer one important method of detecting the disease in its early stages. Cancerous cells often make certain proteins or other molecules that are attached to the cell s membrane and help the cell to grow and divide. These proteins are not found in healthy cells or are much rarer than in cancerous ones and, therefore, can serve as miniature markers for the diseased cells. These markers would make cancer cells easy to detect, but physicians do not usually have an effective tool with which to see them. 

Gao, X., et al. (2004), In vivo cancer targeting and imaging with semiconductor quantum dots, Nat. Biotechnol., 22,8. 

Li HA, Cao ZJ, Zhang YH, Lau CW, Lu JZ (2010) Combination of quantum dot fluorescence with enzyme chemiluminescence for multiplexed detection of lung cancer biomarkers. Anal Meth 2 1236-1242... 

Wu X, Liu H, Hu J, Haley KN, Treadway JA, Larson JP, Ge N, Peale F, Bruchez MP (2003) Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nat Biotechnol 21 41 16... 

Carbon nanotube Plasma polymer coating 0 Quantum dot Anti-cancer drug loaded... 

SELECTIVE FUNCTIONALIZATION OF SEMICONDUCTOR QUANTUM DOTS WITH SHORT PEPTIDES AND INTEGRINS OF CANCER CELLS FOR BIOPHOTONIC APPLICATIONS... 

To examine the role of the peptide selectivity in the binding of QDP complexes to cells, the binding of CGGGRGDS-functionalized and CGGGRVDS-functionalized quantum dots to cancer cells the MDA-MB-435 cell line was used and then directly observed with a fluorescence microscope. Fig. 3 shows MDA-MB-435 cells as viewed with white light exposure. 

Zhang H, Yee D, Wang C. Quantum Dots for Cancer Diagnosis and Therapy. Biol Clin Perspectives 2008 3 83-91. 

Robe A, Pic E, Lassalle HP, et al. Quantum dots in axillary lymph node mapping Biodistribution study in healthy mice. BMC Cancer 2008 8 111. 

---