Cancer bioassays screening tests

U. Saffiotti, Validation of short-term bioassays as predictive screens for chemical carcinogens, in Screening Tests in Chemical Carcinogenesis (R. Montesano, H. Bartsch, and L. Tomatis, eds.), pp. 3-13, International Agency for Research on Cancer (lARC Scientific Publ. No. 12), Lyons, France (1976). 

As screening capacity in the U.S. National Cancer Institute s P388 lymphocytic leukemia (PS) test increased in the 1965-1968 period it began to have a very beneficial impact on the success of our research directed at the discovery of marine animal antineoplastic constituents. The early (6) and more recent 13) evolutionary direction of the NCI antineoplastic and cytostatic evaluation systems has been reviewed. By 1968 extracts of B. neritina reached the confirmed active level and consistently allowed over a 100% increase in life span. Bioassay guided isolation was begun with the PS in vivo system and supplemented from 1975 on with the PS in vitro cell line. The in vivo and in vitro activity... 

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