Cancer-associated mucin

Clinical correlation studies between CA 27.29 levels and CA 15-3 levels typically yield correlation coefficients of >0.95. It has been suggested that the epitope mapping studies reflect that the CA 27.29 antigen is essentially the same breast cancer-associated mucinous antigen detected by the two methods. 

MuCl (cancer-associated mucin) SdAb (singledomain antibody, or diabody) Tobacco Anticancer therapy... 

In addition to exposed peptide motifs, the generation of aberrantly sialylated carbohydrate moieties provides yet another means of differentiating between cells expressing normal or cancer-associated mucins in vivo (see O Sect. 4). Chemical synthesis allows a potentially unlimited number of vaccine formulations to be constmcted incorporating one, or a combination of antigenic mucin-based carbohydrate structures. 

Bhavanandan, V. P., 1991, Cancer-associated mucins and mucin-type glycoproteins, Glycobiology 1 493-503. 

Burchell, J., Papadimitriou, J. T, Boshell, M., Gendler, S., and Duhig, T, 1989, A short sequence, within the amino acid tandem repeat of a cancer-associated mucin, contains immunodominant epitopes, Int. J. Cancer 44 691-696. 

Mucin-like cancer-associated antigens (MCA). MCA findings in CSF are denoted as a marker of metastatic breast cancer. 

Magnani, J. L., Steplewski, Z., Koprowski, H., and Ginsburg, V., 1983, Identification of the gastrointestinal and pancreatic cancer-associated antigen detected by monoclonal antibody 19-9 in the sera of patients as a mucin, Cancer Res. 43 5489-5492. 

CA 125 is a mucin-like glycoprotein antigenic determinant expressed on the surface of coelomic epithelium and human ovarian carcinoma cells however, it does not appear to be specific for ovarian cancer because elevated levels have been reported in breast and colorectal cancers. Studies have shown increased CA 125 levels in patients with ovarian cancer, whereas decreased CA 125 levels in chemotherapy are associated with improved possibility for survival. Some studies have shown failure of CA 125 levels to return to normal after chemotherapy, indicating... 

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