Canadian Coronary Atherosclerosis

Waters D, Higginson L, Gladstone P, Kimball B, LeMay M, Bocuzzi SJ, et al. Atherosclerosis in coronary heart disease effects of monotherapy with an HMGCoA reductase inhibitor on the progression of coronary atherosclerosis as assessed by serial quantitative arteriography the Canadian Coronary Atherosclerosis Intervention Trial. Circulation 1994 89 959-968. 

Waters D, Lesperance J, Gladstone P, Boccuzzi SJ, Cook T, Hudgin R, et al. Effects of cigarette smoking on the angiographic evolution of coronary atherosclerosis. A Canadian Coronary Atherosclerosis Intervention Trial (CCAIT) Substudy. CCATT Study Group. Circulation 19% 94 614-621. 

The average daily consumption of cholesterol in the United States and Canada is now about 450 mg. There appears to be ample evidence that reducing the cholesterol intake may be beneficial to a reduction in mortality from coronary heart disease. Evidence indicates that a 2-4% reduction in coronary artery disease risk may be achieved by decreasing plasma cholesterol by 1% (Lipid Research Clinics Program, 1984 Frick et al., 1987). Various agencies in the United States, Canada and many European countries have recommended that dietary cholesterol consumption be reduced to 300 mg or less. These include the American Heart Association (1988), National Research Council (1989), Canadian Heart and Stroke Foundation, Health and Welfare Canada (1990), European Atherosclerosis Society (1987), and the Consensus Conference, US (1985). 

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