Caloric restriction , in mammals

TAC of blood plasma in rats fed an ethanol-supplemented diet increases, although ethanol is known to induce oxidative stress. The effect is due to ethanol-induced purine degradation and increase in the level of uric acid (G2). TAC of blood plasma in critically ill patients with renal dysfunction is augmented, again due to increase in uric acid level (Ml). Caloric restriction, a procedure known to improve the redox status and prolong the life span of mammals, decreases TAC of rat serum (C12). 

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