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Calcium ryanodine

Sorcin (soluble resistance-related calcium binding protein) was isolated from multidrug-resistant cells and is expressed in a few mammalian tissues such as skeletal muscle, heart, and brain. In the heart, sorcin interacts with the ryanodine receptor and L-type Ca2+-channels regulating excitation in contraction coupling. [Pg.294]

Calsequestrin is the major calcium storage protein of the sarcoplasmic reticulum in skeletal and cardiac muscles. It is highly acidic and has a large capacity for Ca2+. Calsequestrin functions to localize calcium near the junctional face of the terminal cistemae from which calcium can be released into the cytosol via the ryanodine receptor. [Pg.314]

Fill M, Copello JA (2002) Ryanodine receptor calcium release channels. Physiol Rev 82 893-922... [Pg.1099]

Flubendiamide is an example of a new chemical class of insecticides that have been termed phthalic acid diamides (Nauen 2006, Copping and Duke 2007). They are related to the alkaloid ryanodine, which is extracted from Ryania species. Ryanodine affects muscles by binding to calcium channels of the sarcoplasmic reticulum. Ca + ions act as intracellular messengers, and their flux is modulated by calcium channels of this type. The toxic action of ryanodine and synthetic insecticides related to it is due to the disturbance of calcium flux. [Pg.7]

Malignant hyperthermia caused by mutant ryanodine receptor calcium release channels 723... [Pg.713]

Calcium couples muscle membrane excitation to filament contraction. Important work has focused on the proteins present in the T-tubule/SR junction. One protein, an integral component of the T-tubular membrane, is a form of L-type, dihydropyridine-sensitive, voltage-dependent calcium channel. Another, the ryanodine receptor (RyR), is a large protein associated with the SR membrane in the triad that may couple the conformational changes in the Ca2+ channel protein induced by T-tubular depolarization to the Ca2+ release from the SR (Fig. 43-6). [Pg.718]

The first molecule, the Ca2+ channel, is required for coupling at the triad. Skeletal muscle contains higher concentrations of this L-type Ca2+ channel that can be accounted for on the basis of measured voltage-dependent Ca2+ influx because much of the Ca2+ channel protein in the T-tubular membrane does not actively gate calcium ion movement but, rather, acts as a voltage transducer that links depolarization of the T-tubular membrane to Ca2+ release through a receptor protein in the SR membrane. The ryanodine receptor mediates sarcoplasmic reticulum Ca2+ release. The bar-like structures that connect the terminal elements of the SR with the T-tubular membrane in the triad are formed by a large protein that is the principal pathway for Ca2+ release from the SR. This protein, which binds the... [Pg.718]

Gao, J. et al., 2005. Ryanodine receptor-mediated rapid increase in intracellular calcium induced by 7,8-benzo(a)pyrene quinone in human and murine leukocytes, Toxicol. Sci., 87, 419, 2005. [Pg.120]

Martin C, Hyvelin JM, Chapman KE, Marthan R, Ashley RH, Savineau JP 1999 Pregnant rat myometrial cells show heterogeneous ryanodine- and caffeine-sensitive calcium stores. Am J Physiol 277 C243-C252... [Pg.17]

Wayman CP, Gibson A, McFadzean I 1998 Depletion of either ryanodine- or IP3-sensitive calcium stores activates capacitative calcium entry in mouse anococcygeus smooth muscle cells. Pfliiger s Arch 435 231—239... [Pg.90]

Calcium release by ryanodine receptors in smooth muscle... [Pg.108]

Kitazawa T, Kobayashi S, Horiuti K, Somlyo AV, Somlyo AP 1989 Receptor coupled, permeabilized smooth muscle role of the phosphatidylinositol cascade, G proteins and modulation of the contractile response to Ca2+. J Biol Chem 264 5339-5342 Lopez-Lopez JR, Shacklock PS, Balke CW, Wier WG 1995 Local calcium transients triggered by single L-type calcium channel currents in cardiac cells. Science 268 1042-1045 Marks AR, Fleischer S, Tempst P 1990 Surface topography analysis of the ryanodine receptor/ junctional channel complex based on proteolysis sensitivity mapping. J Biol Chem 265 13143-13149... [Pg.118]

Marx SO, Reiken S, Hisamatsu Y et al 2000 PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor) defective regulation in failing hearts. Cell 101 365-376... [Pg.118]

Garaschuk 0, Yaari Y, Konnerth A. (1997). Release and sequestration of calcium by ryanodine-sensitive stores in rat hippocampal neurones. J Physiol (London). 502(pt 1) 13-30. [Pg.451]

Zhang L, Liu Y, Song F et al (2011) Functional SNP in the microRNA-367 binding site in the 3 UTR of the calcium channel ryanodine receptor gene 3 (RYR3) affects breast cancer risk and calcification. Proc Nad Acad Sci USA 108 13653-13658... [Pg.364]

See other pages where Calcium ryanodine is mentioned: [Pg.244]    [Pg.557]    [Pg.310]    [Pg.1143]    [Pg.1303]    [Pg.190]    [Pg.191]    [Pg.401]    [Pg.59]    [Pg.180]    [Pg.156]    [Pg.359]    [Pg.382]    [Pg.382]    [Pg.383]    [Pg.387]    [Pg.387]    [Pg.388]    [Pg.723]    [Pg.17]    [Pg.64]    [Pg.118]    [Pg.167]    [Pg.182]    [Pg.202]    [Pg.202]    [Pg.252]    [Pg.267]    [Pg.190]    [Pg.349]    [Pg.281]    [Pg.179]    [Pg.340]   
See also in sourсe #XX -- [ Pg.1123 ]



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