Calcium human malignancy

Zhuang, L., Peng, J. B., Tou, L., Takanaga, H., Adam, R. M., Hediger, M. A. and Freeman, M. R., 2002, Calcium-selective ion channel, CaTl, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies. Lab Invest 82, 1755-64. 

Weaver AK, Liu X, Sontheimer H (2004) Role for calcium-activated potassium channels (BK) in growth control of human malignant glioma cells. J Neurosci Res 78 224-234... 

There is increasing evidence from epidemiological studies that some of the most frequent human malignancies such as breast (Favero etal. 1998, Lipkin and Newmark 1999, Yang et al. 2000, Grant 2002), prostate (Hayes et al. 1999), and particularly colorectal cancer are associated with poor calcium nutrition (Garland et al. 1985, 1991, Lipkin et al. 1991, Martinez and Willet 1998). A... 

It was also reported that menthol suppressed the viabihty of human malignant melanoma cell line, G-361 and was proposed that the influx of calcium through activation of TRPM8 channels may be responsible for the regulation of cell cycle events leading to cell death in such melanoma cells [27]. 

Calcitonin is also effective in reducing serum calcium levels in life-threatening hypercalcemia however, it is not as rapid or as effective as the bisphosphonates. Subcutaneous administration of salmon (Calcimar) or human (Cibacalcin) calcitonin reduces serum calcium levels within 3 to 5 days in 75 to 90% of malignant hypercalcemias. 

Zhang T, Woods TL, Elder JT. 2002b. Differential responses of S100A2 to oxidative stress and increased intracellular calcium in normal, immortalized, and malignant human keratinocytes. J Invest Dermatol 119(5) 1196—1201. 

Ducreux, S., Zorzato, F., Muller, C., Sewry, C., Muntoni, F., Quinlivan, R., Restagno, G., Girard, T., and Treves, S. (2004). Effect of Ryanodine Receptor Mutations on Interleukin-6 Release and Intracellular Calcium Homeostasis in Human Myotubes from Malignant Hyperthermia-Susceptible Individuals and Patients Affected by Central Core Disease. J Biol Chem 279(42) 43838 16. 

Monnier, N., Procaccio, V., Stieglitz, P., and Lunardi, J. (1997). Malignant -Hyperthermia Susceptibility Is Associated With Mutation of the alpha 1-Subunit of the Human Dihydropyridine-Sensitive L-Type Voltage-Dependent Calcium-Channel Receptor in Skeletal Muscle. Am. J. Hum. Genet. 60 1316—25. 

Dantrolene is a non-centrally acting spasmolytic that is used to treat and prevent malignant hyperthermia in pigs and humans. It limits the amount of calcium being released from the sarcoplasmic reticulum during malignant hyperthermia (Miller 1995). 

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