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Calcitonine gene-related peptide CGRP

Capsaicin, an active ingredient in red pepper, is well known for its ability to release and deplete substance P in sensory C fibers. However, this action is not specific for substance P, as neurokinin A, calcitonin gene-related peptide (CGRP), and somatostatin also are released. [Pg.576]

Human adrenomedullin is a 52-amino acid peptide belonging to the calcitonin/calcitonin gene-related peptide (CGRP)/amylin peptide family. It is synthesized mainly in endothelial cells and elicits vasodilation. [Pg.50]

The sensory neuropeptides, SP, calcitonin-gene-related peptide (CGRP) and somatostatin (SOM) rapidly release histamine from rat serosal mast cells by a non-cytotoxic mechanism [3, 62],... [Pg.147]

Substance P, calcitonin-gene-related peptide (CGRP), and neurokinin A have been identified by immunocytochemistry in primary sensory neurones and in cutaneous sensory nerve terminals and these are often in close proximity to mast cells [54, 56], For example, in Lewis rats that were infected with the parasitic larvae of Nippostrongylis brasiliensis in order to induce a proliferation of mucosal mast cells, nearly two-thirds of the lamina propria mast cells were in intimate contact with peptidergic nerves containing SP and CGRP, while an additional 20% of the mast cells were within 2 gm [54], All three peptides are... [Pg.147]

Figure 4.1. Model of neurogenic inflammation. Stimulation at the skin initiates orthodromic impulses in sensory nerve receptors which elicit antidromic impulses in branching collaterals. The release of neuropeptides such as calcitonin gene-related peptide (CGRP), substance P (SP), and somatostatin (SOM) from nerve terminals ensues and they in turn stimulate the release of histamine (H) and the generation of leukotrienes (LT) from nearby mast cells. These mediators then produce vasodilatation and an increase in vascular permeability. In addition, they act on the nerve terminal to produce further... Figure 4.1. Model of neurogenic inflammation. Stimulation at the skin initiates orthodromic impulses in sensory nerve receptors which elicit antidromic impulses in branching collaterals. The release of neuropeptides such as calcitonin gene-related peptide (CGRP), substance P (SP), and somatostatin (SOM) from nerve terminals ensues and they in turn stimulate the release of histamine (H) and the generation of leukotrienes (LT) from nearby mast cells. These mediators then produce vasodilatation and an increase in vascular permeability. In addition, they act on the nerve terminal to produce further...
Terada, M., Iwanaga, T., Takahasi-Iwanaga, H., Adachi, I., Arakawa, M., and Fujita, T. (1992) Calcitonin gene-related peptide (CGRP)-immunoreactive nerves in the tracheal epithelium of rats an immunohistochemical study by means of whole-mount preparations. Arc/t. Histol. Cytol. 55, 219-233. [Pg.139]

Calcitonin gene-related peptide (CGRP) induces a dose-related increase in penile arterial inflow, cavernous smooth muscle relaxation, cavernous outflow occlusion, and an erectile response. CGRP plus PGEj may be an alternative to penile implants in selected patients. [Pg.739]

Merck and Co., Inc., have patented imidazo[4,5-3]pyridines of the general structure 194, which have been found to be antagonists of calcitonin gene-related peptide (CGRP) receptors, which are useful for the treatment of the symptoms for headache, migraine, and cluster headaches <2005W0013894>. Merck have also patented the... [Pg.483]

Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides, which also includes calcitonin, adrenomedullin, and amylin. CGRP consists of 37 amino acids and displays approximately 30% structural homology with salmon calcitonin. [Pg.388]

BIBN4096BS Antagonist of calcitonin gene-related peptide (CGRP) Blocks some central and peripheral (vasodilator) actions of CGRP Migraine1... [Pg.391]

Daines, R.A., Sham, K.K.C., Tagged, J.J., Kingsbury, W.D., Chan, J., Breen, A., Disa, J., Aiyar, N. Quinine analogs as non-peptide calcitonin gene-related peptide (CGRP) receptor antagonists, Bioorg. Med. Chem. Lett. 1997, 7, 2673-2676. [Pg.552]

Daines, R.A. (SmithKIine Beecham Corporation, USA) Preparation of quinine and quinidine compounds as antagonists of the Calcitonin gene-related Peptide (CGRP) receptor, W09709046 (1997). [Pg.552]

Calcitonin gene-related peptide (CGRP) Parathyroid... [Pg.572]


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See also in sourсe #XX -- [ Pg.82 ]




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Calcitonin gene-related peptide CGRP) receptors

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