Cadmium complexes biology

Munoz, A., Laib, F., Petering, D.H. and Shaw, C.F. Ill (1999) Characterization of the cadmium complex of peptide 49-61 a putative nudeation center for cadmium-induced folding in rabbit liver metallothionein IIA. Journal of Biological Inorganic Chemistry, 4, 495—507. 

Many of the biologically active zinc metalloproteins contain a zinc(II) ion bound to one or more imidazole ligands of the amino add residue histidine. For this reason a large number of studies over an extended period have been carried out on zinc and cadmium complexes of imidazole, substituted imidazoles, histidine and related ligands. There has also been much recent activity in this field much structural information is available. 

Solid State Structures of Cadmium Complexes with Relevance for Biological Systems... 

The selection of the ligands of biological interest for a solid phase structural study of cadmium complexes that are relevant to biological systems took into account those compounds which can be applied as potential antidotes in the... 

PDT candidate. Indeed, it is effective against human leukemia cells,128 284 and as a photobactericide.128 285 286 However, concerns about solubility and cadmium toxicity led to a discontinuation of biological work,128 and in any case the cadmium(II) complex was soon overtaken as a PDT sensitizer by the lutetium(III) derivative (32) (Section 9.22.7.1). 

How much lead is in your municipal drinking water Is platinum present in the urine of a chemotherapy patient Can plants purify water through cadmium uptake Can the amount and location of zinc ions be detected in neurons The detection of trace amounts of metal ions is a central analytical method in environmental and biological chemistry. Often, a reagent that can coordinate to a metal ion of interest is added to a sample solution and the resulting metal complex is detected using analytical instrumentation. Electrochemical and fluorescence detection are two of the most sensitive methods. 

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