Cadmium acute high dose

Reports on chronic effects of cadmium on human liver function are rare. In experimental animals, liver also accumulates substantial amounts of cadmium after both acute and chronic poisoning (Kotsonis and Klaassen 1977, 1978), which results in hepatic injury with both types of exposure (Dudley et al. 1982 Stowe et al. 1972 Faeder et al. 1977). Dudley et al. (1982) demonstrated that liver is a target organ after acute exposure and that the liver injury may play a role in the lethality of animals soon after exposure. The prominent morphological changes after an acute high dose of cadmium... 

Gregus et al. (1992) recently demonstrated that acute administration of high doses of dihydrolipoic acid, a lipid-soluble coenzyme containing two sulfhydryl groups, stimulates hepatic uptake and biliary excretion of mercury. The enhanced uptake presumably results from diffusion of the hydro-phobic metal complex. However, because lipoic acid is normally localized to mitochondria, it may not play a major role in metal uptake under physiological conditions. Mercury and cadmium can also form lipid-soluble complexes with selenium (Magos and Webb 1980), but the mechanisms involved have not been elucidated. 

In rat developmental studies, fetal effects including delayed ossification and decreased locomotor activity occurred at doses that also caused maternal toxicity. Cadmium sulfate injected into the lingual vein of female hamsters on day 8 of pregnancy caused a high incidence of resorption and malformed offspring. Acute necrosis of rat testes followed large doses orally or parenterally, but testicular effects have not been reported thus far in humans." ... 

---