Cadet de Gassicourt

L. C. Cadet de Gassicourt, Qui peuvent servir a l analyse du Cobolt et Histoire d une liqueur fumante, tiree de PArsenic, Mem. Math. Phys. 3, 623 (1760). 

For these reasons, the transition from extracts to pure compounds has been advocated since the birth of modern medicine. Thus, the eminent pharmacist Charles Louis Cadet de Gassicourt (le premier pharmacien de Napoleon) already pledged this in the inaugural issue of the Bulletin de Pharmacie in 1809112 and, thanks to the efforts of generations of phytochemists, the transition could be considered complete, at least for heroic drugs a century later. 

Cadet de Gassicourt, Louis-Claude (1731-1799) adjoint 1766, associe 1770,... 

Cadet de Gassicourt, Louis Claude, and Lavoisier, Antoine-Laurent. Rapport sur un memoire sur la decomposition de I acide nitreux. PV 97, 1778, 87r-89v (March 11) reprinted in Oeuvres de Lavoisier, IV, 298-300. 

Macquer, Pierre-Joseph, and Cadet de Gassicourt, Louis Claude, report on Berthollet s Memoire sur Pair fixe sulfureux tire de Phepatosulfuris. PV 97, 1778, 63v-66v (February 28). 

The first organometal to be reported was cacodyl [tetramethyldiarsine, (CH3)4As2]. It was prepared almost as an afterthought by Cadet de Gassicourt, a Parisian military apothecary, in 1760 (45). Cadet was working on cobalt solutions for use as invisible inks. The two common ores of cobalt, smaltite and cobaltite, both contain arsenic, and arsenic trioxide was formed as a by-product. When he pyrolyzed this oxide with potassium acetate. Cadet got a red-brown liquid that fumed in air and gave off a terrible stench. 

Cadet de Gassicourt (1760) liqueur fu-mante de I arsenique", first organometallic compound (without recognition of structure)... 

Besides conceptual progresses, the formal evolution in the concept of medicines was based on the radical transformation of the nature of medicines. One of the theorists of this trend, Charles Louis Cadet de Gassicourt, reported in the inaugural issue of the Bulletin de Pharmacie (1809) that the use of complex preparations had to be withdrawn in favor of pure substances. Pharmacist and physicians had, first, to classify drugs and their use. This trend was much more convenient with pure substances. Between 1815 and 1820, the first active principles were isolated from plants. At that time, a new era in pharmaceutical chemistry opened. Hereafter, drug activity would not depend on the quality of extracts or tinctures and their inherent variability in active principles. The only variability acceptable in therapeutics would be the patient himself. 

Cadet de Gassicourt, C. L. Considerations sur I Etat actuel de la Pharmacie. Bull. Pharm. 1809,1, 5-12. 

Analyses chimiques des nouvelles eaux min rales, vitrioliques, ferrugineuse, d4-couvertes a Passy, 12 , Paris, 1757 (viii, 133 pp. reprint of analyses by Venel, Bayen, Rouelle, and Cadet de Gassicourt BN 8° Te. 1244). 

Top Organometallic chemistry the French L-C. Cadet de Gassicourt (1713-1799 courtesy of J. Flahaut). Bottom Organometallic drugs the German P. Ehrlich (1854-1915 from a German postage stamp). 

J. Fiahaut, in Charies-Louis Cadet de Gassicourt (1761-1821), royal bastard, pharmacist to the Emperor, Ed. Historiques Tesseidre, Paris, 2001. 

Bremer K, Friis EM, Bremer B (2004) Molecular phylogenetic dating of asterid flowering plants shows Early Cretaceous diversification. Syst Biol 53 496-505 Cadet de Gassicourt L (1817) J Pharmacie 3 495 fide Shellard EJ (1961a)... 

Cadet de Gassicourt L (1817) J pharmacie 3 495 fide SheUard EJ (1961a)... 

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