CA3 pyramidal cells

Normally the dentate granule cells of hippocampus limit excessive activation of their targets, the CA3 pyramidal cells 632... 

The uniqueness of the innervation of their targets by the granule cells underscores their function as gatekeeper. That is, excitatory principal neurons (e.g. CA3 pyramidal cell innervation of its targets in CA1) of mammalian forebrain typically innervate other excitatory neurons directly in great quantitative preference to inhibitory interneurons... 

A second type of NMDA-receptor-independent LTP exists in the mossy-fiber pathway at the dentate granule cell-to-CA3 pyramidal cell synapse [19]. This form of LTP, termed mossy fiber-CA3 LTP, is believed to involve PKA activation in the presynaptic cell which leads to increased neurotransmitter release. However, the exact induction mechanism is not yet clear. 

Schwartzkroin, P. A., and Strafstrom, C. E. (1980) Effects of EGTA on calcium-activated afterhyperpolarization in hippocampal CA3 pyramidal cells. Science, 210 1125-1126. 

Scott, R., and Rusakov, D. A. (2006). Main determinants of presynaptic Ca2+ dynamics at individual mossy fiber-CA3 pyramidal cell synapses. J. Neurosci. 26, 7071-7081. 

Caudle, R. M., Chavkin, C., and Dubner, R. (1994). k,2 Opioid receptors inhibit NMDA receptor-mediated synaptic currents in guinea pig CA3 pyramidal cells. J. Neurosci. 14, 5580-5589. 

Scharfman, H. E., Goodman, J. H., and Sollas, A. L. (2000). Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells Functional implications of seizure-induced neurogenesis. J. Neurosci. 20, 6144-6158. 

Ishizuka N, Weber J, Amaral DG. 1990. Organization of intrahippocampal projections originating from CA3 pyramidal cells in the rat. J Comp Neurol 295 580-623. 

The NRl, NR2A and NR2B genes are all highly expressed in adult dentate granule cells, and in the CA1-CA3 pyramidal cells (Monyer et al., 1992 Watanabe, 1997 Figs. 5, 8 and... 

Gahwiler, B.H. and Brown, D.A. (1085) GABA-B-receptor-activated K+ current in voltage-clamped CA3 pyramidal cells in hippocampal cultures. Proc. Nat. Acad. Scl USA, 82, 1558-1562... 

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