Seizure-Induced Neurogenesis

Ischemic brain injury results in the death of distinct susceptible populations of neurons in the brain. In addition, the injury concurrently triggers cellular repair mechanisms. SVZ precursors can be recruited following transient middle cerebral artery occlusion (Jin et al., 2001 Zhang et al., 2001). In this stroke 

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Scharfman, H. E., Goodman, J. H., and Sollas, A. L. (2000). Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells Functional implications of seizure-induced neurogenesis. J. Neurosci. 20, 6144-6158. 

Parent JM, Lowenstein DH (2002) Seizure-induced neurogenesis Are more neurons good for an adult brain Prog Brain Res 135 121-131. 

Scharfman, HE, Gray, WP (2007) Relevance of seizure-induced neurogenesis in animal models of epilepsy to the etiology of temporal lobe epQepsy. Epilepsia, 48 (Suppl 2) 33-41. 

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