C-Amino

C) Amino-aromatic sulphonic acids. Sulphanilic acid. 

C) AMINO AROMATIC SULPHONIC ACIDS. Sulphanilic or p-amino-benzene sulphonic acid, NH2CJH4SO3H. 

Microbiological procedures which exploit the ability of bacteria and photosynthetic algae to incorporate exogenous labeled precursors such as 14CO2, SO%, and 32pQ3- [ can be used to label complex molecules in cells such as proteins (qv) and nucleic acids (qv), which are then processed to give labeled constituents such as uniformly labeled C-amino acids, C-nucleotides, C-fipids, LS-amino acids, etc (8). 

Jap-KIingermarm reactions, 4, 301 oxidation, 4, 299 reactions, 4, 299 synthesis, 4, 362 tautomerism, 4, 38, 200 Indole, 5-amino-synthesis, 4, 341 Indole, C-amino-oxidation, 4, 299 tautomerism, 4, 298 Indole, 3-(2-aminobutyl)-as antidepressant, 4, 371 Indole, (2-aminoethyl)-synthesis, 4, 278 Indole, 3-(2-aminoethyl)-synthesis, 4, 337 Indole, aminomethyl-reactions, 4, 71 Indole, 4-aminomethyl-synthesis, 4, 150 Indole, (aminovinyl)-synthesis, 4, 286 Indole, 1-aroyl-oxidation, 4, 57 oxidative dimerization catalysis by Pd(II) salts, 4, 252 Indole, 1-aroyloxy-rearrangement, 4, 244 Indole, 2-aryl-nitration, 4, 211 nitrosation, 4, 210 synthesis, 4, 324 Indole, 3-(arylazo)-rearrangement, 4, 301 Indole, 3-(arylthio)-synthesis, 4, 368 Indole, 3-azophenyl-nitration, 4, 49 Indole, 1-benzenesulfonyl-by lithiation, 4, 238 Indole, 1-benzoyl photosensitized reactions with methyl acrylate, 4, 268 Indole, 3-benzoyl-l,2-dimethyl-reactions... 

Richardson, J.S., Richardson, D.C. Amino acid preferences for specific locations at the ends of a helices. Science 240 1648-1652, 1988. 

Amino 2 deoxy d glucose, conversion of hydrochloride to 2 acetamido-2 deoxy d glucose, 46, 2 l-(Ammomcthyl) cycloheptanol, 46, 31 2 Amino 2 methyl 1 propanol in isolation of levopimanc acid 45, 64 c-Amino p nitrobiphenyl, by nitration of o aminobiphenyl, 46, 86 from o,p dimtrobiphenyl, 46, 88 Amino 2 propanone, semicarbazone... 

C. AMINO ACIDS THAT OCCUR BOTH ON THE SURFACE AND IN THE INTERIOR OF PROTEINS... 

Davies and Reider (1996) have given some details of the HIV protease inhibitor CRDCIVAN (INDINAVIR) for which (lS,2R)-c -amino indanol is required. Indene is epoxidized enantioselectively, using the lacobsen strategy (SS-salen Mn catalyst, aqueous NaOH and PiNO), to (lS,2/ )-indene oxide in a two-phase system, in which the OH concentration is controlled. Indene oxide was subjected to the Ritter reaction with MeCN, in the presence of oleum, and subsequent hydrolysis and crystallization in the presence of tartaric acid gives the desired amino indanol. 

Heinrikson, R. L. and Meredith, S. C., Amino acid analysis by reverse-phase high-performance liquid chromatography precolumn derivatization with phenylisothiocyanate, Anal. Biochem., 136, 65, 1984. 

Cascon, S. C., Amino acids in Ilex parag uariensis, Bol Inst Quim Agric, 38, 7, 1955. 

R, 25) -2- [(ethoxycarbonyl) amino] -1 -phenyl-1 -propanol [Brdnsted acid promoted reduction of c/-amino ketone to erythro a-hydroxy amine], 124-125... 

Calder, A.G. Garden, K.E. Anderson, S.E. Lobley, G.E. Quantitation of Blood and Plasma Amino Acids Using Isotope Dilution GC-EI-MS with U- C Amino Acids As Internal Standards. Rapid Com-mun. Mass Spectrom. 1999, 13, 2080-2083. 

Most recently, Baltzer and co-workers have incorporated a lysine-bound nicotinamide into a more complex peptide scaffold [75]. This approach takes advantage of the augmented reactivity of a lysine residue contained in a helix-turn-helix scaffold (as described previously [76]). An adjacent histidine is able to selectively catalyze the formation of an amide bond between activated esters and the lysine c-amino group under aqueous conditions. Thus, reaction of the 42-residue peptide LA-42 withp-nitrophenyl hT-methylnicotinate in an aqueous solution at pH 5.9 yields the nicotinoyl-functionalized peptide (Fig. 27). 

V-1 from acid and alkaline hydrolyzates, SCX-HPLC of amino acids, a mixture of purified crosslinks and hydroxylysine b purified cross-link V-2 c amino acids from an acid hydrolyzate (6 M HCl) of reduced bovine dentin retained on a phenylboronate agarose column after purification as high molecular weight fractions by repeated size exclusion chromatography d as c, alkaline hydrolyzate (2 M KOH). Injections (c, d) resulted from 18 and 52 mg collagen originally hydrolyzed, respectively. 1 = 111 (HP) 2 = V-2 3 = IV 4 = V-1-1 (DHLNL) 5 = HLNL (bovine tendon) 6 = VI (histidinoalanine ) 7 = hydroxylysine 8 = VI (lysinoalanine). 

Recent research on aminocarbenes has led to the development of a very fruitful field. The synthesis of relevant complexes (Scheme 19) such as aminobis(yhde) carbene species (69) [147], cyclic C-amino P-ylides (70) (easily transformed into carbenes) [148] and their corresponding complexes (71) [149], and special ylides (72), which also transform very easily into carbenes by loss of pyridinium group, has been reported. Emphasis has been made on the transformation between ylides and carbenes and on the donor properties of the ylides. From the results obtained the ylides have shown a stronger a-donor behavior compared with the carbenes. 

Another unique synthetic methodology for the carbene phosphine bidentate ligand is the utilization of destabilized C-amino phosphorus ylides 25 as carbene source [66]. Due to the electrostatic repulsion between the two lone pairs on the nitrogen and on the ylidic carbon, the yUdic bond is very labile. Thus, these C-amino phosphorus ylides readily act as 1,6-bidentate ligand precursors by insertion of the metal fragment between the phosphine and carbene centers. 

Triazoles bearing a C-amino substituent have been used as starting materials for several syntheses of biologically important com-... 

Scheme 18 Miller s tripeptide catalyzed KR of a cyclic c -amino alcohol derivative [160]...

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