Butyrolactone receptor proteins

Bibb 2005 Martin and Liras 2010). We will refer to the well-known streptomycin and cephamycin/clavnlanic acid regnlatory cascades as model systems, but the tylosin regulatory cascade and other similar cascades are also well known (Cundliffe 2008). In all these cases the top position in the regulatory cascade is occupied by (i) a butyrolactone receptor protein (BRP) in coordination with its cognate butyrolactone molecnle (Takano 2006), or (ii) a pleiotropic regulator (e.g. AreB dgR) that governs butyrolactone biosynthesis, and therefore, the butyrolactone-dependent cascade. 

Butyrolactone Autoregulators, Inducers of Virginiamycin in Streptomyees virgimae Their Structures, Biosynthesis, Receptor Proteins, and Induction of Virginiamycin Biosynthesis... 

In this chapter, we describe new aspects concerning the induction of virginiamycin production by butyrolactone-type autoregulacors. The structures, biosynthesis of butyro-lactone autoregulators, and their receptor proteins are also reviewed. 

Yamada Y, Nihira T, Sakuda S. Biosynthesis and receptor protein of butyrolactone autorego-lator of Streptomyces virginioe. Actinomycetol 1992 6 1-8. 

Stewart RC (2010) Protein histidine kinases assembly of active sites and their 981 regulation in signaling pathways. Curr Opin Microbiol 13 133-141 Stratigopoulos G, Gandecha AR, Cundliffe E (2002) Regulation of tylosin production and morphological differentiation in Streptomyces fradiae by TylP, a deduced gamma-butyrolactone receptor. Mol Microbiol 45 735-744... 

---