Butoconazol

Because of their limited, activity, small spectmm, and side effects, the older topical antimycotics have generally been surpassed by newer antimycotic chemotherapeutic agents. These newer antimycotics for topical use iaclude the imida2ole derivatives clotrimazole, miconazole, econazole, isoconazole, sulconazole, fenticonazole, oxiconazole, bifonazole, butoconazole, ziaoconazole, tioconazole, and the triazole derivative, terconazole (Table 2) (5—7). The iatroduction of the azole derivatives represents a milestone ia the treatment of mycoses. 

C3H4N2 288-32-4) see Bifonazole Butoconazole Clotrimazole Eprosartan Fenticonazole Isoconazole Ketoconazole Miconazole Neticonazole hydrochloride Omoconazole nitrate Oxiconazole Ozagrel 1/f-imidazole lithium salt (C,H3LiN2 55986-39-5) see Flutrimazole 2-imidazolidinone... 

Butoconazole 2% sustained-release cream, 5 g intravaginally as a single application... 

For pharmaceutical formulations, the simplex method was used by Shek et al. [10] to search for an optimum capsule formula. This report also describes the necessary techniques of reflection, expansion, and contraction for the appropriate geometric figures. The same laboratories applied this method to study a solubility problem involving butoconazole nitrate in a multicomponent system [11],... 

Some imidazole derivatives have turned out to be extremely beneficial for treating fungal infections. They are ketoconazole, miconazole, clotrimazole, econazole, butoconazole, and others. 

Butoconazole Bntoconazole, l-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-IH-imidazole (35.2.12), is synthesized from 4-chlorobenzylmagnesium bromide, which is reacted with epichloridrine to make 4-(4 -chlorophenyl)-l-chlorobutan-2-ol (35.2.10), which is reacted with imidazole in the presence of sodium to make 4-(4 -chlorophenyl)-l-(lH-imidazolyl)butanol-2 (35.2.11). The hydroxyl group in the last is replaced with a chlorine atom npon reaction with thionyl chloride, which is then by the reaction with 2,6-dichlorothiophenol bntoconazole [27,28], is obtained. 

Abelcet) 100 mg/20 mL suspension for injection (AmBisome) 50 mg powder for injection (Amphotec) 50, 100 mg powder for injection Topical 3% cream, lotion, ointment Butoconazole (Gynazole-1, Mycelex-3)... 

Anik, S.T. and Sukumar, L. Extreme verexes design in formulation development solubility of butoconazole nitrate in a multicomponent systdrrf harm. Sci., 70, 897, 1981. 

Butoconazole Femstat 3 Vaginal cream vaginal suppositories Vulvovaginal candidiasis... 

Terconazole and butoconazole nitrate (Femstat) are available as a 2% vaginal cream. They are used at bedtime for 3 d in nonpregnant females. There is a slower response during pregnancy, which requires a 6-d course of treatment. 

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