1- butanol reaction with sodium bromide

Many other alcohols react with HBr, with the reaction mechanism depending on the structure of the alcohol. For example, I-butanol reacts with sodium bromide in concentrated sulfuric acid to give 1-bromobutane by an Sn2 displacement. The sodium bromide/sulfuric acid reagent generates HBr in the solution. 

The enol acetate 77 of 3,4-dihydro-7-methoxy-5-methyl-l-(2l/)-naphthalenone was converted to the acid 78 by ozonolysis and hydrolysis and this by a Wittig reaction with a-methoxyethyltriphenyl-phosphonium chloride gave 79. Compound 79 was converted into 80 by a series of reactions, five in number, which in turn was converted into 81 by reaction with potassium in -butanol. The methyl ester of compound 81, one isomer of which was recognized as that having the correct stereo structure, was converted to 82 by heating with acetic anhydride and 10-camphorsulfonic acid. Subsequent steps involved ozonization, reaction with V,iV -carbonyldiimidazole, lactam formation, reaction with pyridinium bromide perbromide, reaction with sodium hydride, and a further series in which (+ )-oxodendrobine (83) was ultimately obtained. Reduction of the latter to ( )-dendrobine... 

For the conversion of (15)-(+)-3-carene approximately 0.045 mg mL ( 1.2 /tm) CPO was incubated in 100 mM citric acid buffer, pH 3.5 with 25 % (v/v) tert-butanol containing 10 him (15)-(+)-3-carene (final assay concentration) and 10 him sodium chloride, sodium bromide or sodium iodide (final assay concentrations) in a 50 mL vessel on a magnetic stirrer (300 rpm) at room temperature. Hydrogen peroxide was added to a total concentration of 10 ruM over a reaction time of 60 min at a rate of 165 /iM min (165 portions every minute). 

Butoconazole Bntoconazole, l-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-IH-imidazole (35.2.12), is synthesized from 4-chlorobenzylmagnesium bromide, which is reacted with epichloridrine to make 4-(4 -chlorophenyl)-l-chlorobutan-2-ol (35.2.10), which is reacted with imidazole in the presence of sodium to make 4-(4 -chlorophenyl)-l-(lH-imidazolyl)butanol-2 (35.2.11). The hydroxyl group in the last is replaced with a chlorine atom npon reaction with thionyl chloride, which is then by the reaction with 2,6-dichlorothiophenol bntoconazole [27,28], is obtained. 

Bromide ions are oxidized in slightly acidic media with hypochlorite to bromate. The excess of the h)q)ochlorite is taken away by reacting it with sodium formate, and bromide ions are added in excess. The reaction between the bromate and the bromide results in bromine (amplification). The bromine is reacted with the rosaniline reagent (basic fuchsin). The product of this reaction is dissolved in butanol, and the absorbance is measured at 573 mn. 

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