Bunte salts preparation

Disulfides can be prepared by treatment of alkyl halides with disulfide ions and also indirectly by the reaction of Bunte salts (see 10-41) with acid solutions of iodide, thiocyanate ion, or thiourea, or by pyrolysis or treatment with hydrogen peroxide. Alkyl halides also give disulfides when refluxed with sulfur and NaOH, and with piperidinium tetrathiotungstate or piperidinium tetrathiomolybdate. ... 

Dithiins are prepared by vapor phase dealkoxylation of 2,5-dialkoxy-l,4-dithianes (from HSCH2CH(OEt)2 + H+) over alumina at 260-265°C (306 — 307). 2,5-Diaryl derivatives can be prepared from Bunte salts (308 Scheme 46) with acid via the intermediate diol (309). 

Trithianes are rare but routes established for the 3-methyl derivative (226) could provide the basis of more general methods. These include the chlorination of diethyl disulfide and the reaction of the sulfenyl chloride (227) with 1,2-ethanedithiol (74MI22601). 1,2,4,5-Tetrathiane (228) has been prepared by the cyclization of two equivalents of the bis sulfenyl chloride CH2Y2 (229 Y = SCI) or the bis Bunte salt CH2Y2 (230 Y = SSQ3Na) using sodium... 

These dyes are thiosulfate derivatives of sulfur dyes, also known as Bunte salts. They are prepared by reacting water-insoluble sulfur dyes with sulfite and bisulfite in the presence of atmospheric oxygen [Eq. (10)] ... 

Diethyl thioxomalonate, S=C(COOC2H5)2 (1). This reagent can be generated in situ from the Bunte salt (2) prepared by reaction of diethyl chloromalonate with sodium thiosulfate. 

Reaction of the bis Bunte salt (280), prepared from ethylene dibromide and sodium thiosulfate, with formaldehyde in the presence of hydrogen chloride produces the 1,3-dithiolane (4) (30JCS12). 

Thiosulfonates or disulfane 1,1-dioxides, R-S-SO2-R, are thioalkylating agents as the S-S bond is weak and easily cleaved. Sulfide ions therefore react with thiosulfonates in a similar fashion as Bunte salts (see above), and symmetrical alkyl- and aryltrisulfanes may be prepared in high yields by... 

Sulfonate derivatives of cysteine peptides, also referred to as Bunte salts, are prepared by oxidative sulfitolysis of cysteine or cystine peptides (Scheme These derivatives... 

Carboxamido-6-nitrobenzenethiols in aqueous dioxan give the 7-nitrobenzisothiazolones <88JCS(Pl)69i). l,2-Benzisothiazol-3-ones may be prepared from Bunte salts or vice versa (Scheme 13) <85JMC1661, 85TL1753>. 

Sodium thiosulfate can also be used for preparation of thiols it is treated with an alkyl halide which converts it into the S-alkyl thiosulfate (Bunte salt), and this affords the thiol under reducing conditions (required to suppress formation of the disulfide) the Bunte salt need not be isolated. 

A series of 144 N-substltuted S-2-amlnoethyl thiosulfates (Bunte salts) was prepared.Many members gave good protection to mice at doses of 0.07-0.1 of the LD q. A comparison of the pharmacology of a series of Bunte salts with that of the related amlnothlols showed that the Bunte salts were less toxic to mice, but that the differences In radioprotective potency between members of each series could not be predicted accurately. 

Early work [108-110] showed that polymeric disulfides could be prepared from sodium polysulfide and organic dithiosulfates or di-Bunte salt ... 

A new type of thioketone (12), conjugated with an a-ester group, has been obtained by basic cleavage of a thiosulphate (Bunte salt) obtained from the a-chloro-ester. This unstable deep-blue thioketone dimerizes easily to a dithietan. Preparation of the a-dithione (13 R = p-MeaNCgHi) has been reported in detail. In the solid state it exists in the dithione form and in solution in... 

Ruorinated Bunte salts, featuring an —S2O3M group, are prepared by reacting sodium thiosulfate with perfluoroalkylethyl iodide [155,156] ... 

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