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Probenecid Bumetanide

Probenecid has been reported to inhibit renal elimination of many drugs acyclovir (325,326), allopurinol (327), bumetanide (328), cephalosporins (329-334), cidofovir (335), ciprofloxacin (336), famotidine (337), fexofenadine (338), furosemide (339), and oseltamivir (Ro 64-0802) (340). Recent studies have elucidated that probenecid is a potent inhibitor of renal organic anion transporters (OAT1 and OAT3) with the Ki values lower than the unbound plasma concentration of probenecid, indicating the interaction with probenecid includes inhibition of the basolateral uptake process mediated by OAT1 and/or OAT3. [Pg.171]

Extracted acetazolamide, amiloride, bendroflumethiazide, benzthiazide, bumetanide, caffeine, chlorothiazide, chlorthalidone, clopamide, dichlorfenamide, ethaciynic acid, furo-semide, hydrochlorothiazide, metjTapone, probenecid, spironolactone, triamterene, trichlormethiazide... [Pg.249]

Herrdez-Herndndez, R. Campins-Falco, P. Sevillano-Cabeza, A. Improved screening procedure for diuretics. J.Liq.Chromatogr., 1992, 15, 2205-2224 [LOD 10-1000 ng/mL gradient urine hydroxy-methyltheophylline (IS) extracted acetazolamide, amiloride, bendroflumethiazide, bumetanide, chlorthalidone, cyclothiazide, ethacrynic acid, hydrochlorothiazide, probenecid, spironolactone, triamterene]... [Pg.652]

Extracted acetazolamide, amiloride, bendrodumethiazide, benthiazide, bumetanide, can-renone, chlorothiazide, chlorethalidone, cyclothiazide, dichlorphenamide, ethacrynic acid, flumethiazide, furosemide, hydroflumethiazide, methyclothiazide, metolazone, pol5d hia-zide, probenecid, quinethazone, spironolactone, triamterene, trichloromethiazide... [Pg.696]

Brater DC, Fox WR, Chennavasin P. Interaction studies with bumetanide and furosemide. Effects of probenecid and of indomethacin on response to bumetanide in man. J Clin Pharmacol (1981)21,647-53. [Pg.951]

Probenecid decreases the renal clearance of furosemide, but it appears not to alter its overall diuretic effect. Probenecid reduces the natriuretic effects of piretanide, but the clinical relevance of this is not known. Probenecid does not appear to significantly affect bumetanide diuresis. [Pg.951]

Probenecid 1 g did not affect the response of 8 healthy subjects to 500 micrograms or 1 mg of intravenous bumetanide. Another study reported a fall in natriuresis and in the clearance of bumetanide, but this was of minimal clinical importance. ... [Pg.951]

Brater DC, Chennavasin P. Effect of probenecid reqxmse to bumetanide in man. J Clin... [Pg.951]

See other pages where Probenecid Bumetanide is mentioned: [Pg.240]    [Pg.240]    [Pg.207]    [Pg.44]    [Pg.12]    [Pg.208]    [Pg.10]    [Pg.94]    [Pg.208]    [Pg.30]    [Pg.1408]    [Pg.208]   
See also in sourсe #XX -- [ Pg.951 ]



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Bumetanide

Probenecid

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