Building block database

Homologous proteins have similar three-dimensional structures. They contain a core region, a scaffold of secondary structure elements, where the folds of the polypeptide chains are very similar. Loop regions that connect the building blocks of the scaffolds can vary considerably both in length and in structure. From a database of known immunoglobulin structures it has, nevertheless, been possible to predict successfully the conformation of hyper-variable loop regions of antibodies of known amino acid sequence. 

Extraction of Building Blocks from Corporate Databases 201... 

The greatest benefit of RACHEL S component extraction method is that a massive property index of the entire corporate database is created. Along with the atomic coordinates of each component, a wealth of chemical information characterizing each building block is stored. Data such as the size of the component, atom composition, connectivity, ring structure, and electrostatic charges are included. As such, a means of rapidly cross-referencing chemical components on demand is available. 

Distinguishing between observation and experiment, Boyle believed that chemists made observations of what nature does, without being over-ruled by the power and skill of man. These observations were building blocks in the database of natural history. Experiment, in contrast, involved intervention, when nature is guided, and as it were, mastered by art. ) He realized that experiments went beyond the outward appearance of things. They depended on some prior theoretical knowledge, which was itself based on an interpretation of the history of nature. Theory and experiment therefore relied on one another. 

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