Brown seaweeds, fucan

L. Chevolot, A. Foucault, F. Chaubet, N. Kervarec, C. Sinquin, A.-M. Fisher, and C. Boisson-Vidal, Further data on the structure of brown seaweed fucans relationships with anticoagulant activity, Carbohydr. Res., 319 (1999) 154—165. 

Logeart D, Prigent-Richard S, Boisson-Vidal C, et al. (1997). Fucans, sulfated polysaccharides extracted from brown seaweeds, inhibit vascular smooth muscle cell por-liferation. IF Degradation and molecular weight effect. Euro. J. Cell Bio. 74 385-390. 

Nishino, T., Aizu, Y., and Nagumo, T. (1991). Antithrombin activity of a fucan sulfate from the brown seaweed Ecklonia kurome. Thromb. Res. 62,765-773. 

Logeart, D., Prigeant-Richard, S., Jozefonvicz, J., and Letoumeur, D. (1997). Fucan, a sulfated polysaccharide extracted from brown seaweeds, inhibits vascular SMC proliferation Part I. 

Mandal, P., Mateu, C. G., Chattopadhyay, K., Pujol, C. A., Damonte, E. B., and Ray, B. (2007). Structural features and antiviral activity of sulphated fucans from the brown seaweed Cystoseira indica. Antivir. Ckem. Chemother. 18,153-162. 

Sulfated fucan from brown seaweed shows anti-complementary activity by inhibition of the complement system [67]. The polysaccharide has been found to inhibit C4 cleavage which results in the formation of the classical C3 convertase (C4b2a), and to inhibit formation and function of alternative C3 convertase (C3bBb) by interfering with the binding of factor B to C3b and accelerating the decay of factor P-stabilized sites on the alternative C3 convertase (Fig. 7) [67]. 

Blondin C, Fischer E, Boisson-Vidal C, Kazatchkine MD, Jozefonvicz J (1994) Inhibition of complement activation by natural sulfated polysaccharide (fucans) from brown seaweed. Molec Immunol 31 247-253... 

Fucans (sulfated polysaccharides) Cystoseira barbata (brown seaweed) 146... 

Fucan. Several of the brown seaweeds Phaeophyta contain the highly sulfated polysaccharide fucan (fucoidin), which is built up of L-fucose (6-deoxy-L-galactose) residues with sulfate half-ester groups (calcium salt). The polysaccharide contains predominantly a-L-(i -> 2) linkages, ti ether with some a-L-(i - 3) and a-L-(i -> 4) linkages. 

Boisson-Vidal, C., Colliec-Jouault, S., Fisher, A.-M., Tapon-Bretaudiere, J., Sternberg, C., Durand, P., and Josefonvicz, J. (1991) Biological activities of fucans eictracted from brown seaweeds. Drugs of the Future, 16, 539-545. 

Nardella, A., Chaubet, F., Boisson-Vidal, C., Blondin, C., Diuand, P., and Jozefonvicz, J. (1996) Anticoagulant low molecular weight fucans produced by radical process and ion exchange chromatography of high molecular weight fucans extracted from the brown seaweed AscophyUum nodosum. Carbohydr. Res., 289, 201-208. 

Nishino, T Nagumo, T Kiyohara, H Yamada, H. Structural characterization of a new anticoagulant fucan sulfate from the brown seaweed Ecklonia kurome. Carbohydrate Research, 1991, 211, 77-90. 

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