Bronchial artery infusion

Complications Transverse myelitis, aortic rupture, and ulceration of the trachea and esophagus complicate bronchial artery infusion of chemotherapeutic agents. Fever, malaise, and chemical pneumonitis, in addition to skin necrosis, have also been reported. Hemoptysis has occurred in the absence of residual tumor, presumably related to the infusion itself. These complications have minimized the rewards of infusion. 

We found that the NO-releasing agent isosorbide dinitrate (ISDN, Nitrol ) enhanced antitumor activity of SMANCS/Lipiodol when they were infused into the tumor-feeding bronchial artery of lung cancer using a catheter preceding to the infusion of SMANCS arterially. This ISDN infusion enhanced... 

Pharmacokinetic Principles 33 Dose-Response Relationship 34 Intraperitoneal Application 34 Intra-arterial Application 34 Isolated Perfusion Techniques Application Techniques 35 Intracavitary Application 35 Intra-arterial Infusion 36 Regional Perfusion Techniques Stop-Flow Perfusions 36 Isolated Extremity Perfusion (ILP) 37 Hyperthermic Peritoneal Perfusion (HIPEC) 38 Clinical Indications 38 Pancreas Carcinoma 38 Bronchial Carcinoma 39 Extremity Sarcoma 40 Peritoneum 41 Surgical Technique 41 Rationale 42 Clinical Results 43 References 44 Further Reading 45... 

Infusions of cisplatin into the axillary artery have led to a bronchial plexopathy rather than the more commonly described lumbosacral nerve plexus lesion (93). 

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