Bromochloromethanes

In the last case the reaction with bromochloromethane was much faster, and the reaction time (at 20-25°C) was 4 h. 

Other Bromomethanes. Bromochloromethane [74-97-5] (methylene chlorobromide), CH2BrCl, is a clear, colorless Hquid with a characteristic sweet odor and very low freezing point, —88.0°C. Its properties include bp, 68.1°C 1.9229 g/mL 1.4808 heat of vaporization at bp, 232 J /g... 

Bromochloromethane is produced by reaction of an excess of a mixture of methylene chloride and bromine with aluminum at 26 to 30°C (9). 

At 225—275°C, bromination of the vapor yields bromochloromethanes CCl Br, CCl2Br2, and CClBr. Chloroform reacts with aluminum bromide to form bromoform, CHBr. Chloroform cannot be direcdy fluorinated with elementary flourine fluoroform, CHF, is produced from chloroform by reaction with hydrogen fluoride in the presence of a metallic fluoride catalyst (8). It is also a coproduct of monochlorodifluoromethane from the HF—CHCl reaction over antimony chlorofluoride. Iodine gives a characteristic purple solution in chloroform but does not react even at the boiling point. Iodoform, CHI, may be produced from chloroform by reaction with ethyl iodide in the presence of aluminum chloride however, this is not the route normally used for its preparation. 

Bromochloromethane Methyl ether Methyl ethyl ether Methyl ethyl ketone Methyl formate 2-Methyl furan... 

Bromobenzene Bromochlorodifluoromethane Bromochloromethane 1 -Bromo-2-chloropropane Bromoethane... 

Chloroacetophenone (phenacyl chloride) Chlorbenzene (monochlorobenzene) o-Chlorobenzylidene malononitrile (OCBM) Chlorobromomethane/bromochloromethane 2-Chloro-l, 3-butadiene, see p-Chloroprene Chlorodiphenyl (42% chlorine)... 

Reaction of etio acid 67 with N,N-dimethylthioformamidoyl chloride probably gives initially the mixed anhydride 71 this is not isolated but undergoes O to S carbonyl migration to the anhydride 72. Saponification then leads to the thioacid 73. Reaction of the sodium salt of the acid witli bromochloromethane affords cloticasone propionate (74). The corresponding reaction with hioniofluoromethane leads to fluticasone propionate (75) [16]. 

Of bromochloromethanes reacting mainly at C— Br bonds, bromotrichloro-methane has been the most investigated compound. Both the various monomers and diversified routes of initiations were used in the studies of CCl3Br. The addition of bromotrichloromethane to a-olefines under common conditions of radical initiation has been described by a number of examples (ref. 3). 

If the goal of a genetic algorithm application was to find the lowest energy arrangement of the atoms in bromochloromethane (Figure 5.5), the chromosome that defines a possible solution to the problem could be formed as an ordered list of the Cartesian coordinates of each atom ... 

Bromochloromethane was being prepared in a 400 1 reactor by addition of liquid bromine to dichloromethane in presence of aluminium powder (which would form some aluminium bromide to catalyse the halogen exchange reaction). The reaction was started and run for 1.5 h, stopped for 8 h, then restarted with addition of bromine at double the usual rate for 2.5 h, though the reaction did not appear to be proceeding. Soon afterwards a thermal runaway occurred, shattering the glass components of the reactor. 

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