Bromine carbonyl chloride

Furan-2-carbonyl chloride, 5-alkyl-3,4-dichloro-synthesis, 4, 690 Furancarboxamides rotational isomerism, 4, 543 Furan-2-carboxylic acid, 5-acetylamino-ethyl ester reactions, 4, 647 Furan-2-carboxylic acid, amino-properties, 4, 708 Furan-2-carboxylic acid, 5-bromo-nitration, 4, 603, 711 Furan-2-carboxylic acid, 3-methyl-methyl ester bromination, 4, 604 Furan-2-carboxylic acid, 5-methyl-nitration, 4, 602... 

The bromodihydrodibenz[/>,/]az.epine-5-carbonyl chloride 41, prepared by radical bromination of the 10,11-dihydro compound, on heating under pressure with ammonia undergoes dehydrobromination and amidation to yield Carbamazepine (42).122... 

MRH Bromine 1.21/91, carbon tetrachloride 2.89/83, chlorine 3.85/82 Silane burns in contact with bromine, chlorine or covalent chlorides (carbonyl chloride, antimony pentachloride, tin(IV) chloride, etc.) [1], Extreme caution is necessary when handling silane in systems with halogenated compounds, as a trace of free halogen may cause violent explosions [2],... 

Furthermore, in the addition of bromine to 44 (in 1,2-dichloroethane, chloroform or carbon tetrachloride, see Scheme 19) to obtain the trans dibromo derivative99 (47), which is found to be in two main conformers100, the formation of the bromonium ion (46) from 5//-dibenz[ >,/]azepine-5-carbonyl chloride (44) is a reversible step. The formation of the bromonium ion (46) follows the association of reagents in the CT complex (45). 49 reacts with hydrogen bromide through the protonated 48, forming" both the dibromo derivative 47 and the olefin 44. The bromonium ion (46) is the probable intermediate... 

SAFETY PROFILE Mildly toxic by inhalation. Silanes are irritating to skin, eyes, and mucous membranes. Easily ignited in air. Explosive reaction or ignition on contact with halogens or covalent halides (e.g., bromine, chlorine, carbonyl chloride, antimony pentachloride, tin(TV) chloride). Ignites in oxygen. Can react with oxidizers. 

Incompatibilities and Reactivities Halogens (bromine, chlorine, carbonyl chloride, antimony pentachloride, tin(IV) chloride), water ... 

According to H. Moissan, chromium trioxide does not react with chlorine free from hydrogen chloride and K. H. Butler and D. McIntosh observed that the trioxide is insoluble in liquid chlorine, and has no effect on the b.p. of the liquid. According to A. Michael and A. Murphy, a soln. of chlorine in carbon tetrachloride in a sealed tube at 175° forms chromyl and carbonyl chlorides. H. Moissan observed that bromine has no action on the trioxide. I. Walz found that a cone, soln. of chromium trioxide, when poured on iodine, rapidly turns black and assumes a syrupy consistency, and the liquid thus formed does not respond to the tests for free iodic or hydriodic acid chromium hypoiodite may be formed. A mixture of sulphuric acid and chromium trioxide oxidizes iodine to iodic acid. 0. Ruff and H. Krug found that the trioxide is vigorously attacked by chlorine trifluoride. 

Bromo-3-methylthiophene-2-carbonyl chloride was required as an intermediate for the synthesis of an insecticide, 5-(4-bromo-3-methylthien-2-yl)-3-(2-chloro-6-fluorophenyl)-l-methyl-l//-l,2,4-triazole (XR-693) [113]. 3-Methyl-thiophene was selected as a starting material it could be selectively 2-brominated with NBS or exhaustively brominated by bromine to 2,3,5-tribromo-4-methyl-thiophene as shown in Scheme 73 [113]. 

Allylic bromides can also serve as progenitors for nucleophilic organochromium reagents. An elegant example is found in Still and Mobilio s synthesis of the 14-membered cembranoid asperdiol (4) (see Scheme 2).7 In the key step, reduction of the carbon-bromine bond in 2 with chromium(n) chloride in THF is attended by intramolecular carbonyl addition, affording a 4 1 mixture of cembranoid diastereoisomers in favor of the desired isomer 3. Reductive cleav-... 

Carboxylic acids, a-bromination of 55, 31 CARBOXYLIC ACID CHLORIDES, ketones from, 55, 122 CARBYLAMINE REACTION, 55, 96 Ceric ammonium nitrate [Ammonium hexa mtrocerate(IV)[, 55, 43 Chlorine, 55, 33, 35, 63 CHROMIUM TRIOXIDE-PYRIDINE COMPLEX, preparation in situ, 55, 84 Cinnamomtnle, a-phenyl- [2-Propeneni-tnle 2,3-diphenyl-], 55, 92 Copper(l) iodide, 55, 105, 123, 124 Copper thiophenoxide [Benzenethiol, copper(I) salt], 55, 123 CYCLIZATION, free radical, 55, 57 CYCLOBUTADIENE, 55, 43 Cyclobutadieneiron tricarbonyl [Iron, tn-carbonyl(r)4-l,3-cyclo-butadiene)-], 55,43... 

Nickel carbonyl Niobium Nitrates Air, bromine, oxidizing materials Bromine trifluoride, chlorine, fluorine Aluminum, BP, cyanides, esters, phosphorus, tin(II) chloride, sodium hypophos-... 

Benzo[e]thieno[3,2- ]thiepin-10(5Ef)-one 388 can be smoothly reduced with sodium borohydride to the corresponding alcohol, which forms the chloro substituted compound under standard treatment with thionyl chloride (1991CPB2564). Dihydro derivatives of pyrrolo-benzothiazepine 377 have been reported starting from ketone 373 by a carbonyl reduction, bromination and amination sequence (Scheme 76, Section 5.1.1 (1998JMC3763, 2002JMC344, 2004JMC143)). 

With bromine and excess aluminium chloride, 2-acetylfuran was converted into a mixture of 2-acetyl-4,5-dibromofuran (major product) and about equal quantities of the 4- and 5-bromo derivatives. The swamping catalyst effect is operating here. Coordination of the catalyst with the carbonyl function makes the substituent more electronegative, and in the presence of a large excess of Lewis acid catalyst, positions ortho and para to the substituent are deactivated more than the me/a-position [68AG(E)519 82AHC(30)167]. In terms of a 2-acylfuran, this means that... 

Carbon monoxide, 57, 11 Carbonyl compounds, 56, 36 Carboxylic acids, a-bromination of, 55, 31 CARBOXYLIC ACID CHLORIDES, ketones from, 55, 122 CARBYLAMINE REACTION, 55, 96 Carcinogens, list of. 56, 128 58, 168 Carveol, 56, 106 Carveol acetate, 56, 106 Catechols, 58, 125... 

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