Bromide intoxication

Natelson, S and Clark, M. R Estimation of bromide on fingertip blood in bromide intoxication Proc Soc Expt Biol. Med (1955), 90, 723 - 725. 

Conde-Lopez V, Macias-Fernandez JA, Pacheco-Yanez L, et al. 1986. Methyl bromide intoxication. Arch Neurobiol 49 311-328. 

Hauw JJ, Escourolle R, Baulac M, et al. 1986. Postmortem studies on posthypoxic and post-methyl bromide intoxication Case reports. Adv Neurol 43 201-214. 

Holling HE, Clarke CA. 1944. Methyl bromide intoxication. J Royal Navy Med Serv 30 218-224. 

Johnstone RT. 1945. Methyl bromide intoxication of a large group of workers. Ind Med 14 495-497. 

De Haro L, Gastaut J-L, Jouglard J, et ah Central and peripheral neurotoxic effects of chronic methyl bromide intoxication. J Toxicol Clin Toxicol 35(l) 29-34, 1997... 

Deschamps, F.J. Turpin, J.C. (1996) Methyl bromide intoxication during grain store fumigation. Occup. Med., 46, 89-90... 

Herzstein. J. Cullen, M.R. (1990) Methyl bromide intoxication in four field-workers during removal of soil fumigation sheets. Am. J. ind. Med., 17, 321-326... 

E674 Rothenberg, D.M., Bems, A.S., Barkin, R. and Glantz, R.H. (1990). Bromide intoxication secondary to pyridostigmine bromide therapy. JAMA 263, 1 Hill 22. 

Considering the previous use of bromide in clinical medicine for the treatment of neurological and psychic disorders, it is evident that bromide exerts an effect on the CNS. The clinical symptoms of chronic bromide intoxication (so-called bromism) are very well known and described in an almost endless list of publications since... 

Knight HD and Costner GC (1977) Bromide intoxication of horses, goats, and cattle. J Am Vet Med Assoc 171 446-448. 

Mason MF (1936) Halide distribution in body fluids in chronic bromide intoxication. J Biol Chem 113 61-73. 

Diuretics are very effective in the treatment of cardiac oedema, specifically the one related with congestive heartfailure. They are employed extensively in various types of disorders, for example, nephrotic syndrome, diabetes insipidus, nutritional oedema, cirrhosis of the liver, hypertension, oedema of pregnancy and also to lower intraocular and cerebrospinal fluid pressure. In some instances where oedema is not present, the diuresis may be specifically indicated and effected by certain highly specialized dimetics as in hypertension, epilepsy, migraine, glaucoma, anginal syndrome and bromide intoxication. 

Transplacental distribution resulting in neonatal bromide intoxication has been repeatedly described in the literature (Pleasure and Blackburn, 1975). Rauws (1983) stated that the rat fetus appeared to be easily accessible to bromide, and that the elimination from the fetus might be retarded in comparison with the efiminadon from the... 

A knowledge of blood bromide levels is occasionally important as in patients treated with bromosedatives, or anaesthetised with halothane or suffering from drug abuse. The normal bromide level in serum is less than 0.1 mmol dm but in cases of bromide intoxication can rise to above 40 mmol dm and both levels are measurable by the bromide ion-selective electrode as long as the bromine is... 

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