Bisolvon - Bromhexine

It was recently observed that a iplant, Adhatoda vasica, long used in Indian herbal medicine (the source of many therapeutic leads) for the relief of cough and respiratory tract congestion, did appear to reduce the quantity and viscosity of sputum. The plant was studied and its active alkaloid named vasicine. The tricyclic quinazoline structure (XXVIII) was then reduced to fragments and a series of derivatives prepared [350]. From these bromhexine (XXIX, Na 274, Bisolvon)... 

Bromhexine (4 mg Bisolvon given 3 times per day) after several days induced both serous and muciparous cells of human bronchial glands to increase their secretory activity (Gieseking and Baldamus 1968). The lysosome-Hke secretory granules of the serous cells, which are suggested to be enzyme complexes, dissolve after their touch with mucus discharges by the mucous cells. 

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