Brodie, Bernard

Brodie, Bernard Fawn, From Crossbow to H-Bomb , Indiana University Press, Bloomington (1973), 320 pp... 

Brodie, Bernard, Strategy in the Missile Age, Princeton University Press, 1959. 

Udenfriend, Sidney, Weissbach, Herbert, and Brodie, Bernard B., Assay of Serotonin and Related Meubolites, Enzymes, and Drugs. 6... 

Brodie, Bernard, ed. The Absolute Weapon Atomic Power and World Order. New York Har-court. Brace and Co., 1946. 

J. J. Bums, Rose K. Rose, Theodore Chenkin, A. Goldman, Arthur Schulert, and Bernard B. Brodie, J. 

Ortiz de Montellano PR. The 1994 Bernard B. Brodie award lecture structure, mechanism, and inhibition of cytochrome P450. Drug Metab Dispos 1995 23 1181-1187. 

Ortiz De Montellano PR (1995) The 1994 Bernard B. Brodie Award Lecture. Structure, mechanism, and inhibition of cytochrome P450. Drug Metab Dispos 23 1181-1187 Obach RS, Hynh P, Allen MC, Beedham C (2004) Human liver aldehyde oxidase Inhibition by 239 drugs. J Clin Pharmacol 44 7-19... 

Ziegler, D. M. (1991). Unique Properties of the Enzymes of Detoxication, 1990 Bernard B. Brodie Award Lecture, Drug Metab. Disposition, 19 847-852,... 

Quite at the same time, Bernard Brodie studied the antimalarial atabrine (quinacrine) metabolism in order to... 

Coon, M.J. (1981). The 1980 Bernard B. Brodie Award lecture. Drug metabolism by cytochrome P-450 Progress and perspectives. Drug Metab. Dispos. 9, 1-4. 

As early as 1811, Brodie (2) observed that curare effected respiration in warm-blooded animals and that death was due to respiratory failure, and, several years later, Bernard (3) described the location of the physiological action as being at the junction of the nerve and muscle (myoneural junction). Bernard s classical experiments showed that curare blocked the transmission of impulses from nerve to muscle without apparent effects on either the nerve trunk or the muscle fibers themselves. He found that direct stimulation of a curarized muscle produces a contraction. 

To study the effects of drugs, Sydney Udenfriend and Bernard Brodie developed a method for the determination of 5-HT in body tissues. The procedure uses a spectro-photo-fiuorometer to activate and measure emitted fluorescence with a frequency from 250 to 650 pm. 5-HT is activated maximally at 295 pm and emits fluorescent light with a maximum at 550 pm. 

R365 J. R. Halpert, The 2010 Bernard B. Brodie Award Lecture. Structure and Function of Cytochromes P 450 2B From Mechanism-Based Inactivators to X-Ray Crystal Structures and Back , Drug Metab. Dispos., 2011, 39, 1113. 

Gonzalez FJ (2007) The 2006 Bernard B. Brodie award lecture. Cyp2el. Drug Metab Dispos 35 1-8... 

As I have already shown, a few years later Bernard Brodie s students at the National Institutes of Health formalized Travell s results by developing their par-tition hypothesis to explain secretion of drugs by the stomach (Fig. 8-7, pp. 296-298). The hypothesis explained the secretion of basic drugs into acid solution, and they turned it around to explain the absorption of acid drugs from acid but not alkaline solutions. Salicylic acid pKa = 3.0) in 0.1 N HCl was absorbed by a rat s stomach to the extent of 61% in an hour. Likewise, acetanilide pKa = 0.3) was absorbed from an acid solution, but barbital and quinine, each having a high pKa, were not absorbed from a similar solution. 

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