Breeding approaches

Recently, scientists at Vertex have published the BREED approach for determining new compounds with a high likelihood of activity based on three-dimensional binding mode similarity (Fig. 14). When coupled with the automated SiteSorter site alignment calculations in TIP, BREED... 

Esposito, F., Fogliano, V., Cardi, T., Carputo, D., Filippone, E. (2002). Glycoalkaloid content and chemical composition of potatoes improved with nonconventional breeding approaches. J. Agric. Food Chem., 50, 1553-1561. 

De Melo, P.E. 2003. The root systems of onion and Allium fistulosum in the context of organic farming a breeding approach. PhD thesis, Wageningen University, the Netherlands. 

So far, compounds that are toxic to animals have only cropped up in foods developed through conventional breeding approaches. There have not been any adverse health or environmental effects resulting from commercialized GE crops. This may be because foods produced by GE undergo additional scrutiny, or it may be that there... 

As Raoul knows, this of course is not the case for the vast majority of farmers on the Earth, where tolerance to environmental fluctuations such as cold, salt, or submergence can mean the difference between eating or not. Traits such as these are the most difficult to address using standard breeding approaches. In the future, this is where genetic engineering will likely have the most significant human impact. There are already examples of GE plants that can tolerate very cold temperatures (Thomashow 2001). 

Several of these companies now suggest that the T)est of breed approach may not be the best and that one overall system may be a better approach. 

If management is very decentralized, the best that is attainable may he a best of breed approach, in which individual systems are chosen based on their internal functionaUty while integration is of secondary concern. The resulting system will have a relatively low level of integration, DICOM and IHE compliance notwithstanding. 

In addition to ERP (core) systems, a wide variety of business application systems (ERP modules) exist that provide interfaces to these ERP systems. In this context, different variations could be noticed in the development of ERP systems in recent years. While some ERP vendors tend to integrate an extensive range of functionality into their own systems, others follow the best-of-breed approach. For this, the most appropriate ERP modules (e.g., for detailed manufacturing planning, quality management, or personnel time recording) are installed around the... 

TDM solution Integrated approach Best-of-breed approach Point-to-point integration... 

Nevertheless, depending on a single vendor and his single vision on PLM, or on a monolithic software infrastmcture, may have its disadvantage. If cutting edge PLM functionality and individual processes becomes a competitive asset the best-of-breed approach may be more appropriate. This approach addresses the following requirements ... 

The breeding approaches now are directed to combine various resistance factors against pests and diseases in one plant (e.g., Dias [7]). Using the molecular... 

There is a major conflict in developing a software strategy between a best of breed approach and a single integrator approach. In a best of breed ... 

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