Breast cancer statins

Mueck AO, Seeeger H, Wallwiener D (2003) Effect of statins combined with estradiol on proliferation of human receptor-positive and receptor-negative breast cancer cells. Menopause 10(4) 332—336... 

In the five statin megatrials, which collectively randomized over 30,000 patients and had treatment periods of approximately 5 years, new cancers were recorded in over 2000 patients. The numbers of patients with cancer in the active treatment and placebo groups were very similar, as shown in Table III. There was an excess of breast cancer in the pravastatin group in CARE (12 cases vs. 1 in the placebo group), but this is probably an anomalous finding in a small subgroup, as it was not replicable in 4S, LIPID, or AFCAPS, all of which included an appreciable number of female patients (WOS excluded women). The total number of breast cancers in these... 

It has been suspected that low concentrations of serum cholesterol might be associated with an increased risk of cancer or overall mortahty. AH fibrates and statins cause cancer in rodents, but the relevance of this finding to man has been questioned (47). In an epidemiological study these risks were almost non-existent after adjusting for confounding factors. However, in the CARE study, breast cancer occurred in one patient in the control group and 12 in the pravastatin group (48). The incidence of cancers. 

Pancrati statin Increase ROS production, ATP depletion, Av /n, dissipation, caspase activation. Human breast cancer c ell hues MCF-7 andHs 578-T. Alkaloid isolated from Hawaiian spider lily [146] ... 

Kotamraju, S., Williams, C.L., Kalyanaraman, B., 2007. Statin-induced breast cancer cell death role of inducible nitric oxide and arginase-dependent pathways. Cancer Res. 67, 7386—7394. 

Kaye JA, Meier CR, Walker AM, Jick H. Statin use, hyper-lipidaemia, and the risk of breast cancer. Brit. J. Cancer 2002 86 1436-1439. 

The 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (statins) reduce serum cholesterol levels and cardiovascular morbidity and mortality. Statins inhibit cancer cell proliferation in in vivo tumor growth in animal models (Campbell et al. 2006 Kusama et al. 2002 Paragh et al. 2003 Sivaprasad et al. 2006). Moreover, they increased iNOS mRNA and protein expression in the human breast adenocarcinoma cell line (MCF-7). NO cytotoxicity and tumor cell cytotoxicity were inhibited by iNOS inhibitors (Kotamraju et al. 2007). Based on these data, statins which are well known as a class of hyperlipidemic blockbuster drugs and are routinely used for lowering serum cholesterol levels are potential cancer drugs for use as NO inducers. 

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