Brain edema animal models

It is known from animal models with global ischemia and traumatic brain injury that moderate hypothermia attenuates secondary brain damage by reducing cerebral ischemia and postischemic brain edema and preserving the blood-brainbarrier. Even though hypothermia has potent cerebroprotective effects after experimental focal ischemia, clinical studies on hypothermic therapy after MCA infarction were not available until recently. We performed a pilot study investigating the efficacy, feasibility, and safety of induced moderate hypothermia in the therapy of patients with acute, severe MCA infarction and increased ICP. 

Cerebral insufficiency refers to describe the people with age-related decline in mental function and decrease blood flow to the brain cause by clogged arteries. Platelet activating factor (PAF) is an inflammatory mediator, plays an important role in allergy, inflammatory processes, coronary, and cerebral vasoconstriction [178]. The production and release of PAF in the brain under various pathological conditions, including oxidant stress-induced ischemic injury [179]. The efficiency of EGb-761 on cerebral circulation and metabolism has been demonstrated in various models of cerebrovascular insufficiency and showed beneficial effect like cerebral edema in rats intoxicated with triethyltin chloride (TET) [180]. Moreover, oral or intravenous administrations EGb decrease cerebral edema development in gerbils [181]. In an animal study [182], EGb-761 and an extract of local ginkgo... 

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