Brain drug delivery

Pardridge, W. M., Brain drug delivery and blood-brain barrier transport, Drug Deliv., 1996, 3, 99-115. 

Huwyler J, Wu D, Pardridge WM (1996) Brain drug delivery of small molecules using immunoliposomes. Proc Natl Acad Sci USA 93 14164—14169... 

Cerletti A, Drewe J, Fricker G, Eberle AN, Huwyler J (2000) Endocytosis and trans cytosis of an immunoliposome-based brain drug delivery system. J Drug Target 8 435-47... 

Metting TL, Burgio DE, Terry AV Jr, Beach JW, McCurdy CR, Allen DD. (1998). Inhibition of brain choline uptake by isoarecolone and lobeline derivatives implications for potential vector-mediated brain drug delivery. Neurosci Lett. Dec. 11 258(1) 25-28. 

Li JY, et al. Genetically engineered brain drug delivery vectors cloning, expression and in vivo application of an anti-transferrin receptor single chain antibody-streptavidin fusion gene and protein. Protein Eng 1999 12(9) 787-796. 

Allen, D.D., and P.R. Lockman. 2003. The blood-brain barrier choline transporter as a brain drug delivery vector. Life Sci 73 1609. 

R. N. Alyautdin, Y. Kroiter, and D. A. Kharkevitch, Nanoparticles-assisted brain drug delivery, Experimental and Clinical Pharmacology 66(2), 65-68 (2003). 

GaiUard PJ, Brink A, de Boer AG. Diphtheria-toxin receptor-targeted brain drug delivery. Int Congress Series 2005 1277(ll) 185-98. 

The use of SLNs is one of the potential drug delivery methods for targeted brain drug delivery. Tighmess of the endothelial vascular lining, referred to as the blood-brain barrier (BBB), provides a challenge to development of brain drug delivery. In the BBB, capillary endothelial cells protect the... 

Blasi, R, GiovagnoU, S., Schoubben, A., Ricci, M., Rossi. C. Solid lipid nanoparticles for targeted brain drug delivery. Adv. Drug Deliv. Rev. 2007, 59 (6), 454—477. 

Figure 20.9 TAT-Lip liposome brain drug delivery across the BBB both in vitro and in vivo by BCECs of rats.

---