Brain targeted drug delivery

Bodor, N., and P. Buchwald. 2003. Brain-targeted drug delivery Experiences to date. Am J Drug Target 1 13. 

Kumar, M. Misra, A. Babbar, A.K. Mishra, A.K. Mishra, P. Pathak, K. Intranasal nanoemulsion based brain targeting drug delivery system of risperidone. Int. J. Pharm. 2008, 358 (1-2), 285-291. 

Appropriate microbubble/sound combinations can provide novel therapeutic tools. Blood clots can, for example, be broken up by a proper targeted bubble/ focused sound wave association [60]. Such combinations may also enable non-invasive brain surgery, [61] as well as targeted drug delivery via transient acoustically induced opening of the blood-brain barrier [62]. 

Halmos, T., et al. 1997. Synthesis of O-methylsulfonyl derivatives of D-glucose as potential alkylating agents for targeted drug delivery to the brain. Evaluation of their interaction with the human erythrocyte GLUT1 hexose transporter. Carbohydr Res 299 15. 

Wu, D., et al. 2002. Pharmacokinetics and brain uptake of biotinylated basic fibroblast growth factor conjugated to a blood-brain barrier drug delivery system. J Drug Target 10 239. 

G. Somogyi, S. Nishitani, D. Nomi, P. Buchwald, L. Prokai, and N. Bodor, Targeted drug delivery to the brain via phosphonate derivatives. I. Design, synthesis, and evaluation of an anionic chemical delivery system for testosterone, Int. J. Pharm. 166 15 (1998). 

In conclusion, it may be clear that RMT and CMT are important processes for the influx and efflux of substances to and from the BBB endothelial compartment. Changed activity of these processes due to disease, for example, can have serious consequences for functionality and integrity of the BBB. On one hand, this can result in increased para- and transcellular BBB permeability, and therefore, in changed CNS homeostasis. Ultimately, this can lead to CNS diseases, e.g., Alzheimer s or other neurodegenerative diseases (25-27). On the other hand, this offers opportunities for site-specific or targeted drug delivery to the brain when transport processes are selectively upregulated under disease conditions. 

Systemic administration of therapeutic substances for CNS action Intravenous injection for targeted action in the CNS Direct administration of therapeutic substances to the CNS Introduction into cerebrospinal fluid pathways intraventricular, subarachnoid pathways Introduction into the cerebral arterial circulation Introduction into the brain substance Direct positive pressure infusion Drug delivery by manipulation of the blood-brain barrier Drug delivery using novel formulations Conjugates Gels... 

B-Trans Technology Targeted Drug Delivery Across the Blood-Brain Barrier... 

Wang, Y, and Pardridge, W.M. (2008) GDNF fusion protein for targeted-drug delivery across the human blood—brain barrier. Biotechnology and Bioengineering, 100 (2), 387-396. 

Biodegradable nanoparticles have many pharmacentical applications in different areas of human activities like biology and neurology such as targeted drug delivery into the brain for cancer treatment. The developments in bionanoparticles and the nnderstanding of their properties show an optimistic picture in the development of future medicines and related products. 

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