Brain delivery application

Brain delivery of the anticancer drug daunomycin provides an example of the in vivo application of OX26-inununoliposomes [111]. Different formulations of [ H]-daunomycin were i.v. administered to rats either as the free drug or encapsulated in conventional liposomes, sterically-stabilized liposomes, or PEG-conjugated immunohposomes (Table 2.3). Plasma samples were taken at defined time points and after 1 h the animal was killed and drug concentrations in brain tissue were determined. 

Another important application of ONPs is the delivery of xenobiotics into the brain, by going through the blood-brain barrier (BBB). Several papers describe this use [94-97], although further innovation in this field is required as systems currently being investigated still have little absorption and short half-lives. One way around this problem has been found by giving nanoparticulate systems for brain delivery by nasal administration, thus avoiding first-pass metabolism. 

Sukrut, S., Christine, D., 2014. Applications of dendrimers for brain delivery and cancer therapy. Nanomedidne (London) 9 (15), 2403-2414. 

Li JY, et al. Genetically engineered brain drug delivery vectors cloning, expression and in vivo application of an anti-transferrin receptor single chain antibody-streptavidin fusion gene and protein. Protein Eng 1999 12(9) 787-796. 

Penichet ML, et al. An antibody-avidin fusion protein specific for the transferrin receptor serves as a delivery vehicle for effective brain targeting initial applications in anti-HIV antisense drug delivery to the brain. J Immunol 1999 163(8) 4421—4426. 

Although BP 2.94 (36) shows pronounced peripheral activity, it enters the brain only to an insufficient extent. However, the CNS delivery of (/ )-a-methylhistamine (12) at sufficient levels after oral application is a prerequisite for possible central indications like depression or sleep disorders. To optimize the pharmacokinetic profile... 

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