Bovet, Daniel

Bovet, Daniele (1907-1992) Swiss Physiologist Daniele Bovet was born in Neuchatel, Switzerland, on March 23, 1907, to Pierre Bovet, professor of pedagogy at the University of Geneva, and Amy Babut. He graduated from the University of Geneva in 1927 and then worked on a doctorate in zoology and comparative anatomy, which he received in 1929. 

Daniel Bovet Physiology/Medicine First antihistamine drug... 

Daniel Bovet Synthetic compounds that inhibit the action of certain body substances, and especially their action on the vascular system and the skeletal muscles... 

A French research team with Ernest Foumeau (1872-1949), Jacques Trefouel (1897-1977) and Therese Trefouel (bom 1892), Federico Nitti (1905-1947) and Daniel Bovet (1907-1992) at the Pasteur Institute in Paris did the work. Prontosil was inactive on bacilli cultures because it needed... 

The discovery of the antibacterial action of Prontosil prompted a flurry of research activity. At the Pasteur Institute, between July and November 1935, Jacques and Therese Trefouel synthesized 44 azo compounds, of which 18 were sulfonamides Daniel Bovet and Frederic Nitti conducted animal studies on 80 compounds. On November 6, 1935, Bovet and Nitti were doing a study of seven new compounds and had an extra group of mice. They tried p-aminobenzenesulfonamide, which contained the functionality present in the other molecules being tested. They found the white compound to be active, which resulted in a breakthrough in the research that had previously been focused on dyes. In 1937, p-aminobenzenesulfonamide, by now called sulfanilamide in the United States, went on the market. ... 

Antihistamines (Daniel Bovet) Swiss-bom Italian pharmacologist Bovet discovers antihistamines. He is awarded the 1957 Nobel Prize in Physiology or Medicine for his work. 

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