Botryllus schlosseri

Marine tunicates are also a source of brominated tyrosine derivatives. The colonial ascidian Aplidium sp., which was collected in Australia, yielded the novel iodinated tyrosine alkaloids 1973-1975 (1819). Collections of Botryllus sp. and Botryllus schlosseri from the Philippines and the Great Barrier Reef, respectively, have afforded botryllamides A-D (1976-1979) (1820). A Palauan ascidian Botrylloides tyreum produces several new botryllamides, including the brominated botryllamide G (1980) (1821). The simple brominated tyramines 1981 and 1982 were isolated from the New Zealand ascidian Cnemidocarpa bicornuta (1822) and an Indonesian Eudistoma sp. ascidian (1823). 

Rinkevich B, Douek J, Rabinowitz C, Paz G. The candidate Fu/HC gene in Botryllus schlosseri (Urochordata) and ascidians historecognition — an oxymoron Dev Comp Immunol. 2112 36 718-727. 

Isol. from the ascidian Botryllus schlosseri from the Great Barrier Reef and from a B. sp. from the Philippines. Needles (CHCI3). Mp 169-171°. 

Rinkevich, B. and Rabinowitz, C. (1993) In vitro culture of blood cells from the colonial protochordate Botryllus schlosseri. In Vitro Cell. Dev. Biol, 29A, 79-85. 

Botryllamides A D (239-242), which have similar structures as the hemibastadins, but with two additional double bonds, were isolated from the PhiUppine asddian Botryllus sp. and the Australian ascidian Botryllus schlosseri (145). 

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